The role of gut microbiota in human metabolism and inflammatory diseases: a focus on elderly individuals

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2024年1月3日

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Mansoor Khaledi,
Behnam Poureslamfar,
Hashem O. Alsaab,
Shahrad Tafaghodi,
Ahmed Hjazi,
Rajesh Singh,
Ahmed Hussien Alawadi,
Ali Alsaalamy,
Qutaiba A. Qasim,
Fatemeh Sameni

摘要

Background

The gut microbiota plays a crucial role in regulating the host’s immune responses during aging, which was characterized by a different abundance of bacteria in several age groups.

Main body

Gut microbiota dysbiosis is associated with aging, antibiotic exposure, underlying diseases, infections, hormonal variations, circadian rhythm, and malnutrition, either singularly or in combination. The appropriate use of prebiotics and probiotics may be able to prevent or reduce this disruption.

Conclusion

The current review focuses on the gut microbiota composition across the life cycle, factors affecting gut microbiota changes with aging, and interventions to modulate gut microbiota.