Scholarlink

Background <p>Alzheimer’s disease (AD) is characterized by cognitive decline. Gamma-frequency (40&#xa0;Hz) transcranial alternating current stimulation (tACS) may enhance cognition, although its efficacy and neural mechanisms remain unclear. This study evaluated whether 40-Hz tACS improves cognition in individuals with AD and explored the associated neural correlates using resting-state electroencephalography (rs-EEG) and plasma phosphorylated tau.</p> Methods <p>In a randomized, double-blind, sham-controlled trial, 39 participants with AD received either 40-Hz tACS (<i>n</i> = 20) or sham stimulation (<i>n</i> = 19) targeting the left dorsolateral prefrontal cortex (2.0&#xa0;mA, 30&#xa0;min/day, 2 weeks). Cognitive and mood outcomes and rs-EEG spectral and connectivity measures were assessed.</p> Results <p>Compared with sham, 40-Hz tACS was associated with a trajectory-level signal favoring improved global cognition, reduced depressive symptoms, increased frontal–central theta power, enhanced theta band hippocampal–prefrontal connectivity, stronger low-gamma connectivity at the ROI level, and exploratory reductions in plasma p-tau217 and p-tau181.</p> Conclusion <p>Two weeks of low-intensity 40-Hz tACS showed target engagement and a trajectory-level cognitive signal in patients with AD. Biomarker changes were exploratory and require confirmation.</p> Trial registration <p>ClinicalTrials.gov NCT06565143 Date: 2024.08.19.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Effects of 40-Hz transcranial alternating current stimulation on cognition and neural markers in Alzheimer’s disease: a randomized, sham-controlled trial

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月1日

查看全文
  • Miao Fang,
  • Yibing Yan,
  • Wenqian Song,
  • Zhi Geng,
  • Lu Wang,
  • Chenyang Hu,
  • Weiqiang Li,
  • Bo Song,
  • Mengdan Chen,
  • Yulong Dai,
  • Yifan Hu,
  • Shanshan Zhou,
  • Haihua Guo,
  • Gongjun Ji,
  • Panpan Hu,
  • Kai Wang,
  • Xingqi Wu

摘要

Background

Alzheimer’s disease (AD) is characterized by cognitive decline. Gamma-frequency (40 Hz) transcranial alternating current stimulation (tACS) may enhance cognition, although its efficacy and neural mechanisms remain unclear. This study evaluated whether 40-Hz tACS improves cognition in individuals with AD and explored the associated neural correlates using resting-state electroencephalography (rs-EEG) and plasma phosphorylated tau.

Methods

In a randomized, double-blind, sham-controlled trial, 39 participants with AD received either 40-Hz tACS (n = 20) or sham stimulation (n = 19) targeting the left dorsolateral prefrontal cortex (2.0 mA, 30 min/day, 2 weeks). Cognitive and mood outcomes and rs-EEG spectral and connectivity measures were assessed.

Results

Compared with sham, 40-Hz tACS was associated with a trajectory-level signal favoring improved global cognition, reduced depressive symptoms, increased frontal–central theta power, enhanced theta band hippocampal–prefrontal connectivity, stronger low-gamma connectivity at the ROI level, and exploratory reductions in plasma p-tau217 and p-tau181.

Conclusion

Two weeks of low-intensity 40-Hz tACS showed target engagement and a trajectory-level cognitive signal in patients with AD. Biomarker changes were exploratory and require confirmation.

Trial registration

ClinicalTrials.gov NCT06565143 Date: 2024.08.19.