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Head-to-head comparison of tau PET tracers [18F]PI-2620 and [18F]RO948 in non-demented individuals with brain amyloid deposition: the TAU-PET FACEHBI cohort

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2024年11月28日

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  • Matteo Tonietto,
  • Oscar Sotolongo-Grau,
  • Núria Roé-Vellvé,
  • Santiago Bullich,
  • Juan Pablo Tartari,
  • Ángela Sanabria,
  • Ainhoa García-Sánchez,
  • Edilio Borroni,
  • Christopher Galli,
  • Esther Pérez-Martínez,
  • Joan Castell-Conesa,
  • Isabel Roca,
  • Lluís Tárraga,
  • Agustín Ruiz,
  • Andrew W. Stephens,
  • Mercè Boada,
  • Gregory Klein,
  • Marta Marquié,
  • N Aguilera,
  • E Alarcón-Martín,
  • M Alegret,
  • JA Alllué,
  • F Appiani,
  • DM Ariton,
  • M Berthier,
  • U Bojaryn,
  • M Buendia,
  • F Campos,
  • A Cano,
  • P Cañabate,
  • L Cañada,
  • C Cuevas,
  • I de Rojas,
  • S Diego,
  • JM Escudero,
  • A Espinosa,
  • A Gailhajenet,
  • P García-González,
  • F García-Gutiérrez,
  • J Giménez,
  • M Gómez-Chiari,
  • M Guitart,
  • I Hernández,
  • M Ibarria,
  • A Lafuente,
  • N Lleonart,
  • F Lomeña,
  • E Martín,
  • M Moreno,
  • A Morera,
  • L Montrreal,
  • N Muñoz,
  • A Niñerola,
  • AB Nogales,
  • L Núñez,
  • C Olivé,
  • A Orellana,
  • G Ortega,
  • A Páez,
  • A Pancho,
  • E Pelejà,
  • A Pérez-Cordon,
  • V Pérez-Grijalba,
  • M Pascual-Lucas,
  • A Perissinotti,
  • S Preckler,
  • R Puerta,
  • V Pytel,
  • M Ricciardi,
  • J Romero,
  • MI Ramis,
  • M Rosende-Roca,
  • M Sarasa,
  • S Seguer,
  • MA Tejero,
  • J Terencio,
  • M Torres,
  • S Valero,
  • L Vargas,
  • A Vivas,
  • Frederik Barkhof

摘要

Background

Second-generation tau tracers for positron emission tomography (PET) show high affinity for paired helical filaments tau deposits characteristic of Alzheimer´s disease and low off-target binding. Differences in their chemical structure though may lead to variations in their regional tau uptake and off-target signal. In this work, we aimed to compare the in-vivo uptake of tau tracers [18F]PI-2620 and [18F]RO948 in the early stages of the AD continuum.

Methods

Data from the TAU-PET FACEHBI clinical trial (EUDRA-CT 2021–000473-83) were analyzed. All participants were non-demented and underwent tau imaging with [18F]PI-2620 and [18F]RO948 PET within 3 months, amyloid imaging with [18F]Florbetaben and brain magnetic resonance imaging. Tau PET standardized uptake values ratios (SUVR) were calculated in Braak and typical off-target regions using the inferior cerebellar cortex as a reference region.

Results

The cohort consisted of 18 individuals with subjective cognitive decline (n = 13) and mild cognitive impairment (n = 5), with centiloid values ranging from 17 to 159. Both tau tracers showed similar tau pathology distribution but presented a distinct off-target signal pattern on visual read. SUVR measurements for [18F]PI-2620 and [18F]RO948 were highly correlated in all Braak regions (R2 range [0.65–0.80]). Regarding off-target signal, [18F]PI-2620 had higher SUVRs in vascular structures, and [18F]RO948 had higher SUVRs in the skull/meninges.

Conclusions

In a cohort of individuals at early stages of the AD continuum, tau PET tracers [18F]PI-2620 and [18F]RO948 showed similar in-vivo uptake in all Braak regions and distinct off-target signal. These preliminary results support the development of standardized quantification scales for tau deposition that are tracer-independent.

Trial registration

AEMPS EudraCT 2021–000473-83. Registered 30 December 2021.