Elevated Aβ aggregates in feces from Alzheimer’s disease patients: a proof-of-concept study

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2024年10月14日

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Marlene Pils,
Alexandra Dybala,
Anja Schaffrath,
Fabian Rehn,
Janine Kutzsche,
Lara Blömeke,
Markus Tusche,
Pelin Özdüzenciler,
Tuyen Bujnicki,
Victoria Kraemer-Schulien,
Hannes Gramespacher,
Maximilian H.T. Schmieschek,
Michael T. Barbe,
Oezguer A. Onur,
Gereon R. Fink,
Gültekin Tamgüney,
Oliver Bannach,
Dieter Willbold

摘要

Background

Misfolding and aggregation of amyloid β (Aβ), along with neurofibrillary tangles consisting of aggregated Tau species, are pathological hallmarks of Alzheimer’s disease (AD) onset and progression. In this study, we hypothesized the clearance of Aβ aggregates from the brain and body into the gut.

Methods

To investigate this, we used surface-based fluorescence intensity distribution analysis (sFIDA) to determine the Aβ aggregate concentrations in feces from 26 AD patients and 31 healthy controls (HC).

Results

Aβ aggregates were detectable in human feces and their concentrations were elevated in AD patients compared to HC (specificity 90.3%, sensitivity 53.8%).

Conclusion

Thus, fecal Aβ aggregates constitute a non-invasive biomarker candidate for diagnosing AD. Whether digestion-resistant Aβ aggregates in feces are secreted via the liver and bile or directly from the enteric neuronal system remains to be elucidated.