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Background <p>Endometriosis, a common gynecological disorder characterized by ectopic endometrial tissue, has complex epigenetic mechanisms. This study provides a comprehensive bibliometric analysis of research trends in endometriosis epigenetics.</p> Methods <p>Articles on endometriosis epigenetics published from 2005 to 2026 were analyzed using the R package “bibliometrix,” VOSviewer, and CiteSpace to visualize research hotspots, key contributors, and emerging topics.</p> Results <p>A total of 1175 articles were included, with the China leading (442 publications). Fudan University is the top institutions (76 articles, 6.4%), and Professor Taylor Hugh S. was the most prolific author (33 articles, 2.8%). Research hotspots included DNA methylation (notably HOXA10, SF-1, PR-B, ERβ, and GATA factors), histone modifications, and non-coding RNA regulation. Recent trends focus on novel epigenetic biomarkers and targeted therapies.</p> Conclusions <p>This analysis highlights DNA methylation and non-coding RNAs as central in endometriosis epigenetics. Continued research should prioritize discovering biomarkers and translations into clinical practice.</p>

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Research progress and trends on epigenetics and endometriosis: a bibliometric analysis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年8月3日

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  • Xiaohua Li,
  • Yiyun Bai,
  • Sang Luo,
  • Yiran Jin,
  • Junxian Yang,
  • Xiaxia An,
  • Dan Liu

摘要

Background

Endometriosis, a common gynecological disorder characterized by ectopic endometrial tissue, has complex epigenetic mechanisms. This study provides a comprehensive bibliometric analysis of research trends in endometriosis epigenetics.

Methods

Articles on endometriosis epigenetics published from 2005 to 2026 were analyzed using the R package “bibliometrix,” VOSviewer, and CiteSpace to visualize research hotspots, key contributors, and emerging topics.

Results

A total of 1175 articles were included, with the China leading (442 publications). Fudan University is the top institutions (76 articles, 6.4%), and Professor Taylor Hugh S. was the most prolific author (33 articles, 2.8%). Research hotspots included DNA methylation (notably HOXA10, SF-1, PR-B, ERβ, and GATA factors), histone modifications, and non-coding RNA regulation. Recent trends focus on novel epigenetic biomarkers and targeted therapies.

Conclusions

This analysis highlights DNA methylation and non-coding RNAs as central in endometriosis epigenetics. Continued research should prioritize discovering biomarkers and translations into clinical practice.