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<p>We assessed if fasting plasma insulin levels in pregnant women with obesity are associated with newborns’ abdominal fat deposition (dual-energy X-ray absorptiometry) and with cord blood DNA methylation (450k array) in 232 mother–child pairs from the Treatment of Obese Pregnant women (TOP) study. Fasting maternal insulin at 18-20gw was associated with abdominal/total fat mass ratio in newborns independent of multiple potential confounders (<i>β</i> = 0.23[95%CI: 0.01; 0.45], <i>P</i> = 0.041) and with cord blood DNA methylation at CpG sites annotated to <i>C11orf54</i> and <i>RARB</i> (FDR &lt; 10%), both genes potentially involved in metabolic programming. In conclusion, maternal insulin levels in pregnancy were associated with adiposity traits and epigenetics in the offspring. </p>

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Insulin levels at 18–20 gestational weeks in pregnant women with obesity are associated with newborn abdominal fat deposition and DNA methylation in cord blood

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月11日

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  • Alice Maguolo,
  • Josefine Jönsson,
  • Alexander Perfilyev,
  • Allan Vaag,
  • Emma Malchau Carlsen,
  • Kirsten Nørgaard,
  • Paul W. Franks,
  • Kristina M. Renault,
  • Charlotte Ling

摘要

We assessed if fasting plasma insulin levels in pregnant women with obesity are associated with newborns’ abdominal fat deposition (dual-energy X-ray absorptiometry) and with cord blood DNA methylation (450k array) in 232 mother–child pairs from the Treatment of Obese Pregnant women (TOP) study. Fasting maternal insulin at 18-20gw was associated with abdominal/total fat mass ratio in newborns independent of multiple potential confounders (β = 0.23[95%CI: 0.01; 0.45], P = 0.041) and with cord blood DNA methylation at CpG sites annotated to C11orf54 and RARB (FDR < 10%), both genes potentially involved in metabolic programming. In conclusion, maternal insulin levels in pregnancy were associated with adiposity traits and epigenetics in the offspring.