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<p>Reproductive aging, including timing of menarche and menopause, influences long-term morbidity and mortality in women, yet underlying biological mechanisms remain poorly understood. Using DNA methylation-based biomarkers, we assessed associations of age at menarche (<i>N</i> = 1,033) and menopause (<i>N</i> = 658) with epigenetic aging in a nationally representative sample of women ≥ 50 years. Later age at menopause was associated with lower GrimAge epigenetic age deviation (<InlineEquation ID="IEq1"> <InlineMediaObject> <ImageObject Color="BlackWhite" FileRef="13148_2025_1827_Article_IEq1.gif" Format="GIF" Height="14" Rendition="HTML" Resolution="72" Type="Linedraw" Width="17" /> </InlineMediaObject> <EquationSource Format="TEX">\(B\)</EquationSource> <EquationSource Format="MATHML"><math> <mi>B</mi> </math></EquationSource> </InlineEquation> = − 0.10 years, 95% CI: − 0.19, − 0.02). No associations were observed for menarche timing. This suggests a connection between earlier menopause and biological aging, with potential clinical implications for identifying those at high risk for age-related disease.</p>

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Timing of menarche and menopause and epigenetic aging among U.S. adults: results from the National Health and Nutrition Examination Survey 1999–2002

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年2月21日

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  • Saher Daredia,
  • Dennis Khodasevich,
  • Nicole Gladish,
  • Hanyang Shen,
  • Jamaji C. Nwanaji-Enwerem,
  • Anne K. Bozack,
  • Belinda L. Needham,
  • David H. Rehkopf,
  • Julianna Deardorff,
  • Andres Cardenas

摘要

Reproductive aging, including timing of menarche and menopause, influences long-term morbidity and mortality in women, yet underlying biological mechanisms remain poorly understood. Using DNA methylation-based biomarkers, we assessed associations of age at menarche (N = 1,033) and menopause (N = 658) with epigenetic aging in a nationally representative sample of women ≥ 50 years. Later age at menopause was associated with lower GrimAge epigenetic age deviation ( \(B\) B = − 0.10 years, 95% CI: − 0.19, − 0.02). No associations were observed for menarche timing. This suggests a connection between earlier menopause and biological aging, with potential clinical implications for identifying those at high risk for age-related disease.