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Aim <p>The objective of this study is to compare the hemostatic efficacy of oxidised regenerated cellulose powder (Surgicel<sup>®</sup> Powder) and fibrin glue (Tisseel<sup>®</sup>) in a rat model of liver parenchymal haemorrhage, and to evaluate their effects on tissue healing.</p> Results <p>Preoperative haemoglobin and haematocrit values were comparable among the groups (<i>p</i> &gt; 0.05). At 24&#xa0;h, postoperative haemoglobin and haematocrit values differed significantly among the three groups (<i>p</i> = 0.045 and <i>p</i> = 0.042, respectively), with lower values in the saline-compression control group and relatively preserved values in the Surgicel<sup>®</sup> Powder and Tisseel<sup>®</sup> groups. However, no statistically significant difference was identified between the two active treatment groups. Histopathological evaluation revealed no statistically significant between-group differences in necrosis, inflammation, fibrosis, haemorrhage, or granulation tissue formation (<i>p</i> &gt; 0.05).</p>

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Comparative hemostatic efficacy of oxidized regenerated cellulose powder and fibrin glue in a rat model of induced liver parenchymal hemorrhage

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月27日

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  • Berkan Acar,
  • Abdulkadir Çelik,
  • Arslan Hasan Kocamaz,
  • Ömer Kişi,
  • Alper Varman,
  • Selman Alkan,
  • Sıdıka Fındık,
  • İbrahim Kılınç,
  • Mustafa Şentürk,
  • Tevfik Küçükkartallar

摘要

Aim

The objective of this study is to compare the hemostatic efficacy of oxidised regenerated cellulose powder (Surgicel® Powder) and fibrin glue (Tisseel®) in a rat model of liver parenchymal haemorrhage, and to evaluate their effects on tissue healing.

Results

Preoperative haemoglobin and haematocrit values were comparable among the groups (p > 0.05). At 24 h, postoperative haemoglobin and haematocrit values differed significantly among the three groups (p = 0.045 and p = 0.042, respectively), with lower values in the saline-compression control group and relatively preserved values in the Surgicel® Powder and Tisseel® groups. However, no statistically significant difference was identified between the two active treatment groups. Histopathological evaluation revealed no statistically significant between-group differences in necrosis, inflammation, fibrosis, haemorrhage, or granulation tissue formation (p > 0.05).