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Objective <p>This study aimed to explore the correlation between the serum uric acid-to-creatinine ratio (SUA/Scr) and the severity of coronary artery lesions in coronary heart disease (CHD) patients, and evaluate its predictive value for lesion severity.</p> Results <p>Among 528 CHD patients, SUA/Scr showed a stepwise increase with worsening coronary lesion severity, with significant differences in all pairwise comparisons (all <i>P</i> &lt; 0.05). Multivariate logistic regression revealed SUA/Scr as an independent risk factor for severe lesions (OR = 101.844, 95% CI 29.076 ~ 356.726, P &lt; &lt; 0.001). ROC analysis demonstrated superior predictive efficacy of SUA/Scr (AUC = 0.840, cutoff 5.35, sensitivity 80.60%, specificity 75.20%) compared to SUA or Scr alone. SUA/Scr is closely associated with coronary lesion severity and serves as an independent predictor with valuable clinical utility.</p>

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Serum uric acid-to-creatinine ratio as a predictor for the severity of coronary artery lesions

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月17日

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  • Tingfen Wang,
  • Tingyu Wang,
  • Runfeng Zhang

摘要

Objective

This study aimed to explore the correlation between the serum uric acid-to-creatinine ratio (SUA/Scr) and the severity of coronary artery lesions in coronary heart disease (CHD) patients, and evaluate its predictive value for lesion severity.

Results

Among 528 CHD patients, SUA/Scr showed a stepwise increase with worsening coronary lesion severity, with significant differences in all pairwise comparisons (all P < 0.05). Multivariate logistic regression revealed SUA/Scr as an independent risk factor for severe lesions (OR = 101.844, 95% CI 29.076 ~ 356.726, P < < 0.001). ROC analysis demonstrated superior predictive efficacy of SUA/Scr (AUC = 0.840, cutoff 5.35, sensitivity 80.60%, specificity 75.20%) compared to SUA or Scr alone. SUA/Scr is closely associated with coronary lesion severity and serves as an independent predictor with valuable clinical utility.