Anemia and risk of ischemic heart disease among adults with hypertension in Thailand
摘要
We examined the association between anemia and ischemic heart disease (IHD) risk in adults with hypertension in Thailand.
ResultsA total of 14,744 participants were analyzed. The mean hemoglobin (Hb) level was 12.6 ± 1.8 g/dL, and 5,867 participants (39.8%) had anemia. During follow-up, 88 incident IHD cases were recorded, corresponding to an incidence of 6.0 per 1,000 persons. The adjusted risk ratio (aRR) for IHD corresponding to a one g/dL decrease in Hb level was 1.16 (95% confidence interval [CI], 1.02–1.32). Compared with participants without anemia, those with mild and moderate-to-severe anemia were associated with increased IHD risk, with aRRs of 1.73 (95% CI 1.02–2.92) and 1.82 (95% CI 1.02–3.26), respectively. Participants with anemia had an aRR of 1.76 (95% CI 1.09–2.84) for IHD compared to those without. Considering anemia and hypertension control status, individuals with anemia and uncontrolled hypertension were observed to have a higher risk of IHD (aRR 1.98; 95% CI 1.02–3.82) compared to those with no anemia and controlled hypertension. Anemia is a significant, independent risk marker for IHD in Thai adults with hypertension. Screening for anemia could help identify a high-risk subgroup for more intensive cardiovascular monitoring.