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Objective <p>Occupational exposure to ionizing radiation is a known risk factor for genomic instability. This study evaluated whether physicians occupationally exposed to ionizing radiation exhibit higher frequencies of chromosomal alterations compared to unexposed hospital workers, utilizing micronuclei and sister chromatid exchanges as biomarkers.</p> Methods <p>Peripheral blood samples were analyzed from 50 participants: 25 physicians exposed to ionizing radiation (radiologists) and a control group of 25 sex- and age-matched hospital staff with no history of occupational exposure. The cytokinesis-block micronucleus and sister chromatid exchange assays were employed to assess genomic instability.</p> Results <p>No significant differences were observed in hematological parameters between the two groups. However, the frequencies of both micronuclei and sister chromatid exchanges were significantly higher in the exposed physicians compared to the unexposed control group. Chronic occupational exposure to ionizing radiation is associated with measurable signs of genomic instability. These findings highlight the necessity of implementing regular biomonitoring programs for exposed medical personnel to detect early genetic alterations and mitigate potential health risks.</p>

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Micronuclei and sister chromatid exchange in lymphocytes from physicians exposed to ionizing radiation

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月24日

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  • Juan Pablo Meza-Espinoza,
  • Liliana Itzel Patrón-Baro,
  • Nayeli Nieto-Marín,
  • Alberto Kousuke De la Herrán-Arita,
  • Claudia Desireé Norzagaray-Valenzuela,
  • Tomás Adrián Carrillo-Cázares,
  • Salvador Cervín-Serrano,
  • José Johanatan Valdez-Sandoval,
  • Juan Fidel Osuna-Ramos,
  • Verónica Judith Picos-Cárdenas

摘要

Objective

Occupational exposure to ionizing radiation is a known risk factor for genomic instability. This study evaluated whether physicians occupationally exposed to ionizing radiation exhibit higher frequencies of chromosomal alterations compared to unexposed hospital workers, utilizing micronuclei and sister chromatid exchanges as biomarkers.

Methods

Peripheral blood samples were analyzed from 50 participants: 25 physicians exposed to ionizing radiation (radiologists) and a control group of 25 sex- and age-matched hospital staff with no history of occupational exposure. The cytokinesis-block micronucleus and sister chromatid exchange assays were employed to assess genomic instability.

Results

No significant differences were observed in hematological parameters between the two groups. However, the frequencies of both micronuclei and sister chromatid exchanges were significantly higher in the exposed physicians compared to the unexposed control group. Chronic occupational exposure to ionizing radiation is associated with measurable signs of genomic instability. These findings highlight the necessity of implementing regular biomonitoring programs for exposed medical personnel to detect early genetic alterations and mitigate potential health risks.