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Objectives <p>This study explored the schizophrenia patients with autistic traits by analyzing clinical characteristics, inflammatory biomarkers and brain atrophy.</p> Results <p>Multiple regression analysis indicated significant associations. Positive symptom scores were linked to higher platelet count, elevated platelet-to-lymphocyte ratio, greater minimum width of the anterior horn of the lateral ventricle, higher Evans index, and male sex. Negative symptom scores correlated positively with older age, higher body mass index, wider third ventricle, higher neutrophil-to-lymphocyte ratio, and male sex. General psychopathology scores rose with older age and greater minimum ventricular width, as did total the Positive and Negative Syndrome Scale (PANSS) scores. The PANSS Autism Severity Score increased with higher neutrophil-to-lymphocyte ratio, greater ventricular widths (minimum anterior horn and third ventricle), older age, larger maximum external cranial diameter, and higher Evans index.</p>

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Associations of inflammatory biomarkers with brain atrophy and clinical scores in schizophrenia patients with autistic features

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月10日

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  • Jin Wang,
  • Jie Shen,
  • Yu Pang,
  • Jihui Liu,
  • Lili Zhao,
  • Momo Sun,
  • Yang Yang

摘要

Objectives

This study explored the schizophrenia patients with autistic traits by analyzing clinical characteristics, inflammatory biomarkers and brain atrophy.

Results

Multiple regression analysis indicated significant associations. Positive symptom scores were linked to higher platelet count, elevated platelet-to-lymphocyte ratio, greater minimum width of the anterior horn of the lateral ventricle, higher Evans index, and male sex. Negative symptom scores correlated positively with older age, higher body mass index, wider third ventricle, higher neutrophil-to-lymphocyte ratio, and male sex. General psychopathology scores rose with older age and greater minimum ventricular width, as did total the Positive and Negative Syndrome Scale (PANSS) scores. The PANSS Autism Severity Score increased with higher neutrophil-to-lymphocyte ratio, greater ventricular widths (minimum anterior horn and third ventricle), older age, larger maximum external cranial diameter, and higher Evans index.