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Objective <p>To develop a simple, rapid and cheap catalytic method for methoxylation of aryl halides for late-stage functionalization and demonstrate its utility in isotopic labelling.</p> Results <p>A ligand-free, microwave-assisted method for methoxylation of aryl halides using copper(II) hydroxide as catalyst has been explored. The new method is simple and cheap, afforded synthetically useful yields in some cases, but does not seem to give generally higher yields in more substituted systems. The viability of isotopic labelling using the method has been demonstrated by <sup>13</sup>C-incorporation at the methoxy group.</p>

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A simple, ligand-free Cu(OH)2-catalyzed methoxylation of aryl halides

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月14日

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  • Karoline Nordli,
  • Xavier Jouffroy,
  • Meda Surdokaitė,
  • Melina Flakowski,
  • Anna Walter,
  • Jørn H. Hansen

摘要

Objective

To develop a simple, rapid and cheap catalytic method for methoxylation of aryl halides for late-stage functionalization and demonstrate its utility in isotopic labelling.

Results

A ligand-free, microwave-assisted method for methoxylation of aryl halides using copper(II) hydroxide as catalyst has been explored. The new method is simple and cheap, afforded synthetically useful yields in some cases, but does not seem to give generally higher yields in more substituted systems. The viability of isotopic labelling using the method has been demonstrated by 13C-incorporation at the methoxy group.