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<p>This study conducts a comprehensive assessment of four sequencing platforms: GenoLab M (Genemind), NovaSeq X (Illumina), T7 (MGI) and Salus Pro (Salus), focusing on different performance metrics related to methylation data. By analyzing data from plasma cfDNA samples, we assessed key metrics including sequencing quality, CpG coverage, data efficiency, and methylation level consistency. These findings aim to provide valuable insights into the consistency of sequencing platforms for researchers and laboratories when integrating multiple methylation datasets for analysis.</p>

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Comparative analysis of four sequencing platforms for methylation sequencing

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月16日

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  • Jinxia Guan,
  • Chuanchun Yang,
  • Hongjun Gao,
  • Shuanping Liu,
  • Min Zheng,
  • Yongjun Li,
  • Baochen Du,
  • Changling Zhang,
  • Yuanyuan Guo,
  • Qi Wang,
  • Luyang Zhao,
  • XiaoLiang Han

摘要

This study conducts a comprehensive assessment of four sequencing platforms: GenoLab M (Genemind), NovaSeq X (Illumina), T7 (MGI) and Salus Pro (Salus), focusing on different performance metrics related to methylation data. By analyzing data from plasma cfDNA samples, we assessed key metrics including sequencing quality, CpG coverage, data efficiency, and methylation level consistency. These findings aim to provide valuable insights into the consistency of sequencing platforms for researchers and laboratories when integrating multiple methylation datasets for analysis.