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Objectives <p>This study aims to investigate the relationship between <i>H. pylori</i> infection and types of tumor markers (CEA and CA19-9) among Yemeni gastric cancer patients, comparing the frequency of these markers in patients with and without <i>H. pylori</i> infection.</p> Results <p>Serum CEA and CA19-9 levels were measured among 85 patients with <i>H. pylori</i> infection (cases) and 85 without (controls). The median CEA levels were 7.05 ng/mL in <i>H. pylori</i> positive group and 7.14 ng/mL in negative group. The median CA19-9 levels were 33 U/mL in <i>H. pylori</i> positive group and 32 U/mL in negative group. No significant differences were found in the serum levels of CEA (<i>p</i> = 0.44) or CA19-9 (<i>p</i> = 0.94) between the two groups. However, a significant association was observed between <i>H. pylori</i> infection and gastric cancer site in cardia and fundus regions (<i>p</i> = 0.047). This study found no significant association between <i>H. pylori</i> infection and types of tumor markers (CEA and CA19-9) among Yemeni gastric cancer patients. However, the significant association between <i>H. pylori</i> infection and site of gastric cancer in cardia and fundus regions needs further investigations to reveal the associated mechanisms.</p>

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Association between Helicobacter pylori infection and the types of tumor markers among Yemeni gastric cancer patients: a case-control study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月12日

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  • Gamil Taher Abdulmughni,
  • Afeef Said Al-Nabhi,
  • Amal Adnan Al-Sheibani,
  • Naif Mohammed Al-Haidary,
  • Arwa Mohammed Othman,
  • Kamal Hamoud Jahzar,
  • Asma’a Ahmed Al-hnhna

摘要

Objectives

This study aims to investigate the relationship between H. pylori infection and types of tumor markers (CEA and CA19-9) among Yemeni gastric cancer patients, comparing the frequency of these markers in patients with and without H. pylori infection.

Results

Serum CEA and CA19-9 levels were measured among 85 patients with H. pylori infection (cases) and 85 without (controls). The median CEA levels were 7.05 ng/mL in H. pylori positive group and 7.14 ng/mL in negative group. The median CA19-9 levels were 33 U/mL in H. pylori positive group and 32 U/mL in negative group. No significant differences were found in the serum levels of CEA (p = 0.44) or CA19-9 (p = 0.94) between the two groups. However, a significant association was observed between H. pylori infection and gastric cancer site in cardia and fundus regions (p = 0.047). This study found no significant association between H. pylori infection and types of tumor markers (CEA and CA19-9) among Yemeni gastric cancer patients. However, the significant association between H. pylori infection and site of gastric cancer in cardia and fundus regions needs further investigations to reveal the associated mechanisms.