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Objective <p>This study aimed to compare the associations of the triglyceride-glucose (TyG) index and its obesity-combined derivatives (TyG-BMI, TyG-WC, TyG-WHtR) with carotid artery plaques in a cohort of postmenopausal women.</p> Results <p>Among 435 postmenopausal women studied, the prevalence of carotid plaques was 36.6% (<i>n</i> = 159). Compared to the non-plaque group, women with plaques were older and had higher triglyceride levels and TyG index (all <i>P</i> &lt; 0.01). In multivariable logistic regression analysis, after full adjustment for confounders including age, LDL-C, and cardiometabolic histories, only the TyG index maintained an independent association with plaque presence (OR = 1.471, 95% CI 1.044–2.073, <i>P</i> = 0.027). In contrast, none of the derivatives (TyG-BMI, TyG-WC, TyG-WHtR) showed significant associations. The TyG index demonstrated a modest predictive value for plaques (AUC = 0.593, <i>P</i> = 0.001), which was superior to its derivatives.</p>

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Association of the triglyceride-glucose index and its derived indices with carotid artery plaques in postmenopausal women: a cross-sectional study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月24日

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  • Xiaoqin Chen,
  • Xueru Ding,
  • Min Liang,
  • Li Li,
  • Xia Dong,
  • Xiang Zhao

摘要

Objective

This study aimed to compare the associations of the triglyceride-glucose (TyG) index and its obesity-combined derivatives (TyG-BMI, TyG-WC, TyG-WHtR) with carotid artery plaques in a cohort of postmenopausal women.

Results

Among 435 postmenopausal women studied, the prevalence of carotid plaques was 36.6% (n = 159). Compared to the non-plaque group, women with plaques were older and had higher triglyceride levels and TyG index (all P < 0.01). In multivariable logistic regression analysis, after full adjustment for confounders including age, LDL-C, and cardiometabolic histories, only the TyG index maintained an independent association with plaque presence (OR = 1.471, 95% CI 1.044–2.073, P = 0.027). In contrast, none of the derivatives (TyG-BMI, TyG-WC, TyG-WHtR) showed significant associations. The TyG index demonstrated a modest predictive value for plaques (AUC = 0.593, P = 0.001), which was superior to its derivatives.