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<p>Nursing home acquired pneumonia (NHAP) is a leading cause of mortality in long-term care facilities (LTCFs), primarily resulting from the macro-aspiration of opportunistic pathogens colonizing the upper respiratory tract. While multiple bacterial species can cause NHAP, <i>Streptococcus pneumoniae</i> is the most common, and pneumococcal vaccination remains the primary preventative measure. Oral hygiene interventions are also increasingly explored as a complementary strategy to reduce pathogen colonization, although their reported effectiveness has been mixed, likely due to differences in how individual pathogens respond. To better understand these discrepancies, we examined whether pathogen-specific colonization patterns vary in response to oral health behaviors in elderly LTCF residents. We collected longitudinal oral and nasal colonization data for four key NHAP-associated pathogens, along with oral health survey responses, and pneumococcal vaccination status. Better oral health behaviors predicted reduced colonization with <i>S. pneumoniae</i> and <i>Haemophilus influenzae,</i> both of which were more commonly found in oral samples in this population. There was no relationship with <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa,</i> which were more commonly found in the nasal cavity. Our findings suggest that oral hygiene interventions will only impact NHAP risk for pathogens primarily colonizing the oral cavity, potentially explaining the mixed outcomes in prior studies.</p>

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Exploring the impact of oral health and vaccination on pneumonia-causing bacteria: insights from predictive modeling

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月21日

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  • Ryann N. Whealy,
  • Skylar Timm,
  • Tara N. Furstenau,
  • Alexander Roberts,
  • Sara Maltinsky,
  • Sydney Wells,
  • Kylie Drake,
  • Kayla Ramirez,
  • Candice Bolduc,
  • Ann Ross,
  • Talima Pearson,
  • Viacheslav Y. Fofanov

摘要

Nursing home acquired pneumonia (NHAP) is a leading cause of mortality in long-term care facilities (LTCFs), primarily resulting from the macro-aspiration of opportunistic pathogens colonizing the upper respiratory tract. While multiple bacterial species can cause NHAP, Streptococcus pneumoniae is the most common, and pneumococcal vaccination remains the primary preventative measure. Oral hygiene interventions are also increasingly explored as a complementary strategy to reduce pathogen colonization, although their reported effectiveness has been mixed, likely due to differences in how individual pathogens respond. To better understand these discrepancies, we examined whether pathogen-specific colonization patterns vary in response to oral health behaviors in elderly LTCF residents. We collected longitudinal oral and nasal colonization data for four key NHAP-associated pathogens, along with oral health survey responses, and pneumococcal vaccination status. Better oral health behaviors predicted reduced colonization with S. pneumoniae and Haemophilus influenzae, both of which were more commonly found in oral samples in this population. There was no relationship with Staphylococcus aureus and Pseudomonas aeruginosa, which were more commonly found in the nasal cavity. Our findings suggest that oral hygiene interventions will only impact NHAP risk for pathogens primarily colonizing the oral cavity, potentially explaining the mixed outcomes in prior studies.