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Objective <p>Toxoplasmosis, caused by <i>Toxoplasma gondii</i> (<i>T. gondii</i>), is a common zoonotic disease worldwide. Novel therapeutic options are required due to the limited effectiveness and side effects of existing treatments. This study aims to evaluate the in vitro antiparasitic activity of linalool at various concentrations against tachyzoites of the <i>T. gondii</i> RH strain, in comparison with a positive control (saponin 0.2%) and a negative control (no treatment), using flow cytometric analysis.</p> Results <p>The flow cytometry results revealed a dose-dependent anti-<i>Toxoplasma</i> activity for linalool, with 18.37%, 36.77%, 38.75%, 47.57%, and 50.63% mortality rates at the concentrations of 37.5, 75, 150, 300, and 600&#xa0;µg/mL, respectively. The mortality rate at the concentration of 1200&#xa0;µg/mL (74.44%) was slightly higher than that of the positive control group (67.87%). Our findings provide primary evidence for the extracellular potential of linalool against <i>T. gondii</i> tachyzoites. This study provides a rationale for further research to evaluate linalool’s intracellular and in vivo efficacy and safety.</p>

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Linalool as a potential agent against Toxoplasma gondii: an in vitro study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月19日

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  • Kimia Goudarzi,
  • Keivan Sahebi,
  • Ehsan Zandi,
  • Qasem Asgari,
  • Fatemeh Askari,
  • Aref Teimouri

摘要

Objective

Toxoplasmosis, caused by Toxoplasma gondii (T. gondii), is a common zoonotic disease worldwide. Novel therapeutic options are required due to the limited effectiveness and side effects of existing treatments. This study aims to evaluate the in vitro antiparasitic activity of linalool at various concentrations against tachyzoites of the T. gondii RH strain, in comparison with a positive control (saponin 0.2%) and a negative control (no treatment), using flow cytometric analysis.

Results

The flow cytometry results revealed a dose-dependent anti-Toxoplasma activity for linalool, with 18.37%, 36.77%, 38.75%, 47.57%, and 50.63% mortality rates at the concentrations of 37.5, 75, 150, 300, and 600 µg/mL, respectively. The mortality rate at the concentration of 1200 µg/mL (74.44%) was slightly higher than that of the positive control group (67.87%). Our findings provide primary evidence for the extracellular potential of linalool against T. gondii tachyzoites. This study provides a rationale for further research to evaluate linalool’s intracellular and in vivo efficacy and safety.