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Objective <p>Develop a one-pot, three-step procedure for effective access to diverse unsymmetrical 1,1-diarylalkenes from readily accessible reagents, catalysts and substrates.</p> Results <p>A three-step, one-pot procedure for the synthesis of unsymmetrical 1,1-diarylalkenes via a dibromination-elimination-Suzuki Miyaura coupling sequence has been designed and a range of reaction conditions have been screened. Although high selectivities can be achieved in some cases, the overall reaction typically proceeds in low to moderate isolated yields albeit up to 70% was observed. The reaction is compatible with a range of substituent patterns on the arylboronic acid and different styrenes.</p>

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A three-step, one-pot strategy to unsymmetrical 1,1-diarylalkenes

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月10日

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  • Vijayaragavan Elumalai,
  • Hanna Bähr,
  • Karoline Nordli,
  • Stian R. Martinsen,
  • Cole Funk,
  • Jørn H. Hansen

摘要

Objective

Develop a one-pot, three-step procedure for effective access to diverse unsymmetrical 1,1-diarylalkenes from readily accessible reagents, catalysts and substrates.

Results

A three-step, one-pot procedure for the synthesis of unsymmetrical 1,1-diarylalkenes via a dibromination-elimination-Suzuki Miyaura coupling sequence has been designed and a range of reaction conditions have been screened. Although high selectivities can be achieved in some cases, the overall reaction typically proceeds in low to moderate isolated yields albeit up to 70% was observed. The reaction is compatible with a range of substituent patterns on the arylboronic acid and different styrenes.