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Background <p>Ischemic stroke (IS), a leading global health problem, is caused by interrupted blood flow in the brain, often due to clotting or artery constriction. Long non-coding RNAs (lncRNAs), particularly HOX transcript antisense intergenic RNA (HOTAIR), are pivotal in stroke pathophysiology.</p> Aim <p>This study focused on the expression levels of HOTAIR lncRNA in ischemic stroke patients.</p> Methods and materials <p>: This comparative cross-sectional study with 100 participants: 50 IS patients and 50 patients without IS serving as controls. The study gathered demographic data, disease specifics, and medication history. Blood samples were analyzed for HOTAIR lncRNA expression levels.</p> Results <p>This study showed significantly higher expression levels of HOTAIR lncRNA among IS patients compared to the control group (5.73 ± 0.75 vs. 2.35 ± 0.29; <i>P</i> &lt; 0.001), with an average increase of 3.19 units compared to the control group (<i>P</i> &lt; 0.001) after adjusting the independent variables. Additionally, participants with hypertension had an average increase of 0.36 units in of HOTAIR lncRNA expression compared to the control group (<i>P</i> = 0.041).</p> Conclusion <p>Our study found that HOTAIR lncRNA levels are significantly higher in IS patients and may be associated with a history of hypertension. diseases. This suggests that HOTAIR lncRNA could be a useful biomarker for stroke and related conditions.</p>

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Investigating long non-coding RNA (lncRNA) HOTAIR expression changes in ischemic stroke patients

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月24日

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  • Alia Saberi,
  • Niloufar Nabavi,
  • Amirreza Ghayeghran,
  • Zivar Salehi,
  • Yaser Moaddabi,
  • Mohammad Ebrahim Ghaffari,
  • Haniyeh Haghanipor,
  • Sara Khoshdooz,
  • Ali Bonyad

摘要

Background

Ischemic stroke (IS), a leading global health problem, is caused by interrupted blood flow in the brain, often due to clotting or artery constriction. Long non-coding RNAs (lncRNAs), particularly HOX transcript antisense intergenic RNA (HOTAIR), are pivotal in stroke pathophysiology.

Aim

This study focused on the expression levels of HOTAIR lncRNA in ischemic stroke patients.

Methods and materials

: This comparative cross-sectional study with 100 participants: 50 IS patients and 50 patients without IS serving as controls. The study gathered demographic data, disease specifics, and medication history. Blood samples were analyzed for HOTAIR lncRNA expression levels.

Results

This study showed significantly higher expression levels of HOTAIR lncRNA among IS patients compared to the control group (5.73 ± 0.75 vs. 2.35 ± 0.29; P < 0.001), with an average increase of 3.19 units compared to the control group (P < 0.001) after adjusting the independent variables. Additionally, participants with hypertension had an average increase of 0.36 units in of HOTAIR lncRNA expression compared to the control group (P = 0.041).

Conclusion

Our study found that HOTAIR lncRNA levels are significantly higher in IS patients and may be associated with a history of hypertension. diseases. This suggests that HOTAIR lncRNA could be a useful biomarker for stroke and related conditions.