Objective
The aim of this study was to determine CD4 cell count and viral load count association and its joint clinical risk factors among adult TB/HIV co-infected patients. The purpose of this research was leads to contribute improved planning and execution of screening programs, regular follow-ups, and prevention measures.
Result
The baseline variability for viral load ( \(\:1129.934\) ) was higher than CD4 cell (819.797). Furthermore, the correlation matrix (R) shows that the baseline subject-specific CD4 cell and viral load were negatively correlated (− 0. \(\:5624\) ). There was also a negative relationship between the subject-specific change CD4 cell and baseline viral load (- \(\:0.8649\) ), subject-specific baseline CD4 cell, and the patient-specific change of viral load (-0.6513), longitudinal trajectory (association of evolution) for the two random slopes \(\:(\) -0.9413). Then, there was very strong negative relationship between subject-specific change CD4 cell and viral load over time. Visit time \(\:\:(\:\beta\:=-0.1694,\:0.0714)\) , white blood cell \(\:\:(\:\beta\:=-\text{0.0645,0.7430})\) , good \(\:(\:\beta\:=-1.2491,\:0.6940)\) and fair \(\:(\:\beta\:=-0.0236,\:0.4109\) ) adherence, hemoglobin ≥ 11 g/dl \(\:(\:\beta\:=-2.3610,\:0.4870)\) , baseline CD4 cell ≥ 200 cells/mm3 \(\:(\:\beta\:=-1.3694,\:0.6694)\) , and baseline viral load < 10,000 copies/mL \(\:\left(\:\beta\:=-1.4683,\:0.9541\right),\:\) hematocrit \(\:\left(\:\beta\:=0.4875,-0.3649\right),\:\) and monocytes of patients \(\:\:(\:\beta\:=-0.0274,\:1.0064)\) were a joint determinates for viral load and CD4 cell, respectively.
