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Objectives <p>This study aims at determination of the roles of five apoptosis-related genes, namely <i>CASP2</i>,<i> CASP8</i>,<i> BCL2</i>,<i> HULC</i> and <i>PVT1</i> in the pathoetiology of periodontitis <i>via</i> measurement of their expressions in both peripheral blood and tissues of affected persons.</p> Results <p><i>CASP2</i> was over-expressed in gingiva of patients compared with healthy subjects (RME = 24.56, <i>P</i> &lt; 0.001), and in both affected females and males (RME = 30.53, <i>P</i> = 0.03 and RME = 20.59, <i>P</i> = 0.01, respectively). <i>BCL2</i> was higher in affected tissues compared with controls (RME = 32.28, <i>P</i> &lt; 0.001) and in affected tissues of males versus controls (RME = 69.03, <i>P</i> &lt; 0.001). Finally, <i>HULC</i> had lower level in the blood of patients (RME = 0.21, <i>P</i> = 0.01) and in the blood of female patients compared with normal females (RME = 0.15, <i>P</i> = 0.01). Other comparisons yielded no significant results. <i>BCL2</i> and <i>CASP2</i> had the highest diagnostic values for separation of diseased gingival tissues from normal ones. <i>HULC</i> has the best values in the distinction of blood samples of affected persons from control persons. Combination of transcript levels of <i>CASP2</i>,<i> CASP8</i>,<i> BCL2</i>,<i> HULC</i> and <i>PVT1</i> changed AUC to 0.84 and 0.72 in tissues and blood samples, respectively. To conclude, these genes might be regarded as putative contributors in the pathophysiology of periodontitis.</p>

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The investigation of apoptosis-related genes in periodontitis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月12日

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  • Arezou Sayad,
  • Fatemeh Hashemian,
  • Leila Gholami,
  • Masoud Jamali,
  • Elham Badrlou,
  • Saba Sadeghpour,
  • Naghme Nazer,
  • Sheyda Khalilian,
  • Soudeh Ghafouri-Fard

摘要

Objectives

This study aims at determination of the roles of five apoptosis-related genes, namely CASP2, CASP8, BCL2, HULC and PVT1 in the pathoetiology of periodontitis via measurement of their expressions in both peripheral blood and tissues of affected persons.

Results

CASP2 was over-expressed in gingiva of patients compared with healthy subjects (RME = 24.56, P < 0.001), and in both affected females and males (RME = 30.53, P = 0.03 and RME = 20.59, P = 0.01, respectively). BCL2 was higher in affected tissues compared with controls (RME = 32.28, P < 0.001) and in affected tissues of males versus controls (RME = 69.03, P < 0.001). Finally, HULC had lower level in the blood of patients (RME = 0.21, P = 0.01) and in the blood of female patients compared with normal females (RME = 0.15, P = 0.01). Other comparisons yielded no significant results. BCL2 and CASP2 had the highest diagnostic values for separation of diseased gingival tissues from normal ones. HULC has the best values in the distinction of blood samples of affected persons from control persons. Combination of transcript levels of CASP2, CASP8, BCL2, HULC and PVT1 changed AUC to 0.84 and 0.72 in tissues and blood samples, respectively. To conclude, these genes might be regarded as putative contributors in the pathophysiology of periodontitis.