Objective <p>The aim of this research is to identify the main determinants of patients’ confidence/trust in the emergency department (ED), the effects of these determinants on confidence/trust in the ED and potential mediators in this regard.</p> Results <p>Through satisfaction, the effect of doctors, perceived waiting time for triage, information about possible delays in receiving treatment or waiting times, and meeting expectations lead to confidence/trust in the ED by 66%, 61%, 61%, and 61% of the variation, while through perceived quality of healthcare (PQHC), the effect of privacy, doctors, accessibility and availability, perceived waiting time to be called back by the doctor after the examinations and/or tests, and meeting expectations lead to confidence/trust in the ED by 64%, 64%, 65%, 63%, and 65% of the variation, with statistically significant results (<i>p</i> &lt; 0.01).</p>