Objective <p>Patient education at the time of discharge using models which aim to improve self-care behaviors can significantly contribute to patients’ adoption of a healthy lifestyle and treatment adherence. This is a randomized controlled clinical trial with no blinding in which we tested two groups of intervention control. 90 patients having undergone coronary angioplasty were allocated to an intervention (<i>N</i> = 45) and a control group randomly (<i>N</i> = 45). Data were collected from January to October 2022. The data collection instruments comprised angioplasty patients’ treatment adherence questionnaire, Walker’s health-promoting lifestyle profile questionnaire, and Snyder’s Hope Scale. Data analysis was performed using SPSS version 23. To analyze the data, we used descriptive statistics. Accordingly, inferential statistics applied included chi-square, independent-samples t-test, and repeated measures (ANOVA). Significance level was considered as <i>p</i> &lt; 0.05.</p> Results <p>The mean scores of lifestyle, hope, and treatment adherence in the intervention group were significantly higher than those of the control group as measured immediately and three months after the intervention (<i>p</i> &lt; 0.05). The study results revealed that using discharge program based on Orem’s self-care model positively impacted the lifestyle, hope, and treatment adherence of patients having experienced coronary angioplasty.</p> Iranian registry of clinical trials <p>IRCT registration number: IRCT20190917044802N5.</p> Registration date <p>17/7/2022.</p>