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Background <p>Hypoxia is a common symptom of lung cancer. Proliferation and neovascularization mediated by hypoxia-inducible factors (HIF) influence several adaptations. It has recently been established that naringenin (NAR) and its nanoparticles are chemo-preventive flavonoids in lung cancer.</p> Aim <p>Adjust HIF activity by reviving oxygen-sensing enzyme activity while considering possible therapeutic targets.</p> Method <p>The bindings of NAR to target proteins were examined using computational modeling techniques. Additionally, NAR nanoparticles (NARNPs) were synthesized and characterized. Normal fibroblast cells and A549 cells were used to determine cytotoxicity. Colorimetric analysis of α-ketoglutarate detection for hydroxylases.</p> Results <p>According to molecular modeling, NAR and target proteins have a high affinity. The PHD and FIH activities in A549 are significantly stimulated.</p> Conclusion <p>NAR and NARNPs diminish hypoxia in lung cancer by stimulating oxygen-sensing hydroxylases.</p>

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Naringenin-loaded nanoparticles modulate HIF-driven oxygen-sensing pathways in lung adenocarcinoma cells

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年2月12日

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  • Eman M. Ragab,
  • Doaa M. El Gamal,
  • Tarek M. Mohamed,
  • Abeer A. Khamis

摘要

Background

Hypoxia is a common symptom of lung cancer. Proliferation and neovascularization mediated by hypoxia-inducible factors (HIF) influence several adaptations. It has recently been established that naringenin (NAR) and its nanoparticles are chemo-preventive flavonoids in lung cancer.

Aim

Adjust HIF activity by reviving oxygen-sensing enzyme activity while considering possible therapeutic targets.

Method

The bindings of NAR to target proteins were examined using computational modeling techniques. Additionally, NAR nanoparticles (NARNPs) were synthesized and characterized. Normal fibroblast cells and A549 cells were used to determine cytotoxicity. Colorimetric analysis of α-ketoglutarate detection for hydroxylases.

Results

According to molecular modeling, NAR and target proteins have a high affinity. The PHD and FIH activities in A549 are significantly stimulated.

Conclusion

NAR and NARNPs diminish hypoxia in lung cancer by stimulating oxygen-sensing hydroxylases.