The silent predictors: exploring galectin-3 and Irisin’s tale in severe COVID-19

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2024年10月27日

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Valentina N. Nikolic,
Višeslav Popadic,
Slobodan M. Jankovic,
Nenad Govedarović,
Stevan Vujić,
Jelica Andjelković,
Lazar S. Stosic,
Nikola Č. Stevanović,
Marija Zdravkovic,
Zoran Todorovic

摘要

Objective

This study aimed to evaluate the roles of galectin-3 and irisin as biomarkers in predicting severe outcomes in COVID-19 patients.

Results

We analyzed serum levels of galectin-3 and irisin in 59 patients with severe COVID-19 and 30 healthy controls. Elevated galectin-3 levels were associated with increased risks of mortality, need for intensive care, and severe acute respiratory distress syndrome. The optimal cut-off value for galectin-3 was 13.47 ng/ml, with a sensitivity of 72.7% and specificity of 76.6%. Irisin levels did not differ significantly between survivors and non-survivors at admission or on the 3rd day post-admission, but approached significance on the 7th day. These findings suggest that galectin-3 could be a valuable prognostic biomarker for severe COVID-19 outcomes, while irisin’s role remains to be clarified in further studies.