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Stability of ascorbic acid in human aqueous humor

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2024年6月26日

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  • Sakae Ito,
  • Mayumi Nagata,
  • Yuka Takino,
  • Akihito Ishigami,
  • Tadashi Senoo

摘要

Objective

The stability of ascorbic acid (AA) in the human aqueous humor (AqH) remains unclear. This study aimed to investigate the stability of AqH AA under varying conditions (27, 4, − 20, and − 80 °C) without acidification.

Results

Rapid AA degradation occurred at 27 °C. At 4 °C, a significant 12.2% degradation was observed after 24 h. Storage at − 20 °C resulted in a notable 37.5% degradation after 28 days, whereas storage at − 80 °C resulted in 10.7% degradation after 28 days. Unacidified AqH samples recorded early decomposition at 27 °C and 4 °C. In conclusion, it is recommended to conduct measurements within 28 days for samples stored at − 80 °C.