Transplanting human infant gut microbiome species into Galleria mellonella

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2024年4月30日

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Harriet C.C. Gooch,
Marjorie Labedan,
Lindsay J. Hall,
Anthony Maxwell

摘要

Objective

Study of the human infant gut microbiome requires the use of surrogate mammalian species such as mice. We sought to investigate the usefulness of the greater wax moth larva, Galleria mellonella, as an alternative.

Results

We have analysed the native gut microbiome of Galleria and developed methods for clearing the native microbiome and introducing species from human infant faecal samples. We find that some species, e.g. enterococci, are more successful at recolonisation, but that others, e.g. Bifidobacterium, are less so. The work paves the way for using Galleria rather than mice in this and similar work.