Long-term outcome of combined radiologic and surgical strategy for the management of biliary complications after pediatric liver transplantation

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2024年3月20日

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Ana M. Calinescu,
Sébastien Monluc,
Stephanie Franchi-Abella,
Dalila Habes,
Gabrielle Weber,
Marion F. Almes,
Jerome Waguet,
Emmanuel Jacquemin,
Virginie Fouquet,
Jordi Miatello,
Geraldine Hery,
Catherine Baujard,
Emmanuel Gonzales,
Sophie Branchereau,
Florent Guérin

摘要

Objectives

We aimed to analyze the risk factors for management failure of BC after pediatric liver transplantation (pLT) by retrospectively analyzing primary pLT performed between 1997 and 2018 (n = 620 patients).

Results

In all, 117/620 patients (19%) developed BC. The median (range) follow-up was 9 (1.4–21) years. Patient survival at 1, 5 and 10 years was 88.9%, 85.7%, 84.4% and liver graft survival was 82.4%, 77.4%, and 74.3% respectively. Graft not patient survival was impaired by BC (p = 0.01). Multivariate analysis identified the number of dilatation courses > 2 (p = 0.008), prolonged cold ischemia time (p = 0.004), anastomosed multiple biliary ducts (p = 0.019) and hepatic artery thrombosis (p = 0.01) as factors associated with impaired graft survival. The number of dilatation courses > 2 (p < 0.001) and intrahepatic vs anastomotic stricture (p = 0.014) were associated with management failure. Thus, repeated (> 2) radiologic dilatation courses are associated with impaired graft survival and management failure. Overall, graft but not patient survival was impaired by BC.