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Background <p>While high-intensity training improves physiological functions, it also induces significant metabolic stress, leading to a higher incidence of hyperuricemia among athletes compared to the general population. However, existing metabolomic studies on the association between high-intensity exercise and hyperuricemia remain limited, lacking mechanistic exploration of the link between acute exercise stress and chronic disease risk. This study aimed to investigate the potential metabolic associations between acute exercise stress and chronic hyperuricemia through using untargeted metabolomics, while identifying disease-related biomarkers.</p> Methods <p>This study employed LC-MS-based untargeted metabolomics. First, a self-controlled intervention was conducted in 41 normouricemic judo athletes to analyze immediate changes in serum metabolites before and immediately after high-intensity resistance exercise. Subsequently, a validation study was performed in a specific cohort to compare the resting metabolomic profiles between athletes with hyperuricemia and normouricemic controls.</p> Results <p>High-intensity resistance exercise induced significant alterations primarily in glycerophospholipid metabolism. Specifically, lysophosphatidylcholines (LysoPC) were markedly upregulated, whereas phosphatidylcholines (PC) were significantly downregulated immediately after exercise. LysoPC levels showed significant correlations with multiple clinical indices, and a subsequent comparative analysis between hyperuricemic and normouricemic athletes further identified differential metabolites closely associated with hyperuricemia risk.</p> Conclusions <p>This study explored the potential metabolic associations between acute exercise stress and chronic hyperuricemia. Key lipid metabolites, represented by LysoPC, hold promise as potential biomarkers. However, owing to the absence of recovery-phase data, the long-term relationship between these transient post-exercise changes and chronic hyperuricemia requires further validation.</p> Trial registration <p>Chinese Clinical Trial Registry (ChiCTR), ChiCTR2600126268. Registered 5 June 2026 (retrospectively registered).</p>

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Serum metabolomic profiling of exercise response and hyperuricemia status in athletes: a two-part exploratory study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月31日

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  • Siqi Yu,
  • Liju Fan,
  • Xiaochen Huang,
  • Xiaoqing Xing,
  • Lili Xing,
  • Jing An,
  • Guannan Zhang

摘要

Background

While high-intensity training improves physiological functions, it also induces significant metabolic stress, leading to a higher incidence of hyperuricemia among athletes compared to the general population. However, existing metabolomic studies on the association between high-intensity exercise and hyperuricemia remain limited, lacking mechanistic exploration of the link between acute exercise stress and chronic disease risk. This study aimed to investigate the potential metabolic associations between acute exercise stress and chronic hyperuricemia through using untargeted metabolomics, while identifying disease-related biomarkers.

Methods

This study employed LC-MS-based untargeted metabolomics. First, a self-controlled intervention was conducted in 41 normouricemic judo athletes to analyze immediate changes in serum metabolites before and immediately after high-intensity resistance exercise. Subsequently, a validation study was performed in a specific cohort to compare the resting metabolomic profiles between athletes with hyperuricemia and normouricemic controls.

Results

High-intensity resistance exercise induced significant alterations primarily in glycerophospholipid metabolism. Specifically, lysophosphatidylcholines (LysoPC) were markedly upregulated, whereas phosphatidylcholines (PC) were significantly downregulated immediately after exercise. LysoPC levels showed significant correlations with multiple clinical indices, and a subsequent comparative analysis between hyperuricemic and normouricemic athletes further identified differential metabolites closely associated with hyperuricemia risk.

Conclusions

This study explored the potential metabolic associations between acute exercise stress and chronic hyperuricemia. Key lipid metabolites, represented by LysoPC, hold promise as potential biomarkers. However, owing to the absence of recovery-phase data, the long-term relationship between these transient post-exercise changes and chronic hyperuricemia requires further validation.

Trial registration

Chinese Clinical Trial Registry (ChiCTR), ChiCTR2600126268. Registered 5 June 2026 (retrospectively registered).