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Background/Objectives <p>LAS is common in adolescents, yet early management strategies differ. The traditional PRICE + NSAIDs protocol focuses on short-term symptom relief, whereas the PEACE and LOVE framework emphasizes education, early optimal loading, and progressive exercise. This study compared functional recovery between these two approaches.</p> Methods <p>A prospective randomized study enrolled 76 adolescents (12–17 years) with first-time LAS, allocated to PRICE + NSAIDs or PEACE and LOVE using a computer-generated randomization sequence with concealed envelope allocation; 65 completed follow-up (PRICE n = 32; PEACE and LOVE n = 33). Functional performance was assessed at 1–2, 5–7, and 12–15 weeks using Biodex isokinetic dynamometry and the Y-Balance Test composite score (YBT-CS). Outcomes were expressed as side-to-side deficits (uninjured − injured limb) and analyzed using two-way mixed repeated-measures analysis of variance, with Group (PRICE + NSAIDs vs. PEACE and LOVE) as the between-subject factor and Time (1–2, 5–7, and 12–15 weeks) as the within-subject factor.</p> Results <p>Significant main effects of time were observed for IN strength at 60°/s (F = 5.73, p = 0.006) and 120°/s (F = 10.15, p &lt; 0.001), EV strength at 120°/s (F = 6.82, p = 0.003), ankle ROM at 60°/s (F = 12.79, p &lt; 0.001) and 120°/s (F = 13.09, p &lt; 0.001), and YBT CS (F = 6.91, p = 0.002), indicating progressive recovery across follow-up. No significant group effects or time × group interactions were detected for any outcome (all p &gt; 0.05).</p> Conclusions <p>Both rehabilitation protocols were associated with progressive functional recovery following adolescent LAS. No statistically significant between-group differences or differential recovery trajectories were detected over 12–15 weeks. These findings suggest that an active, education-focused rehabilitation approach yields functional outcomes comparable to traditional PRICE + NSAIDs management in the short term. Larger studies with longer follow-up are required to determine whether clinically meaningful differences exist between protocols.</p> Trial registration <p>ClinicalTrials.gov: NCT07287020; registered 3 December 2025 (retrospectively registered).</p>

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PRICE (Protection, Rest, Ice, Compression, Elevation) vs. PEACE and LOVE (Protection, Elevation, Avoid anti-inflammatories, Compression, Education and Load, Optimism, Vascularization, Exercise) in adolescent lateral ankle sprain rehabilitation: a randomized prospective comparative study of muscle strength and dynamic balance

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  • 发表日期：

    2026年3月17日

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  • Matas Meškauskas,
  • Saulius Rutkauskas,
  • Miglė Misiūnienė,
  • Juozas Žumbakys,
  • Jūratė Tomkevičiūtė,
  • Dalius Malcius,
  • Emilis Čekanauskas

摘要

Background/Objectives

LAS is common in adolescents, yet early management strategies differ. The traditional PRICE + NSAIDs protocol focuses on short-term symptom relief, whereas the PEACE and LOVE framework emphasizes education, early optimal loading, and progressive exercise. This study compared functional recovery between these two approaches.

Methods

A prospective randomized study enrolled 76 adolescents (12–17 years) with first-time LAS, allocated to PRICE + NSAIDs or PEACE and LOVE using a computer-generated randomization sequence with concealed envelope allocation; 65 completed follow-up (PRICE n = 32; PEACE and LOVE n = 33). Functional performance was assessed at 1–2, 5–7, and 12–15 weeks using Biodex isokinetic dynamometry and the Y-Balance Test composite score (YBT-CS). Outcomes were expressed as side-to-side deficits (uninjured − injured limb) and analyzed using two-way mixed repeated-measures analysis of variance, with Group (PRICE + NSAIDs vs. PEACE and LOVE) as the between-subject factor and Time (1–2, 5–7, and 12–15 weeks) as the within-subject factor.

Results

Significant main effects of time were observed for IN strength at 60°/s (F = 5.73, p = 0.006) and 120°/s (F = 10.15, p < 0.001), EV strength at 120°/s (F = 6.82, p = 0.003), ankle ROM at 60°/s (F = 12.79, p < 0.001) and 120°/s (F = 13.09, p < 0.001), and YBT CS (F = 6.91, p = 0.002), indicating progressive recovery across follow-up. No significant group effects or time × group interactions were detected for any outcome (all p > 0.05).

Conclusions

Both rehabilitation protocols were associated with progressive functional recovery following adolescent LAS. No statistically significant between-group differences or differential recovery trajectories were detected over 12–15 weeks. These findings suggest that an active, education-focused rehabilitation approach yields functional outcomes comparable to traditional PRICE + NSAIDs management in the short term. Larger studies with longer follow-up are required to determine whether clinically meaningful differences exist between protocols.

Trial registration

ClinicalTrials.gov: NCT07287020; registered 3 December 2025 (retrospectively registered).