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Background <p>Coenzyme Q10 (CoQ10), a vital mitochondrial antioxidant, may enhance cardiovascular recovery and delay fatigue in athletes. This double-blind, randomized, placebo-controlled trial investigated CoQ10’s effects on cardiac stress markers and exercise performance in 16 professional soccer players.</p> Methods <p>Participants received either CoQ10 (<i>n</i> = 8) or placebo (<i>n</i> = 8) for 30 days and completed exhaustive aerobic cycling tests pre- and post-supplementation. Blood samples were collected at six time points to analyze GDF-15, NT-proBNP, and hs-TnT levels.</p> Results <p>In the CoQ10 group, GDF-15 rose post-exercise (PreEx1-PostEx1: +8.84%, <i>p</i> = 0.003; PreEx2-PostEx2: +5.37%, <i>p</i> = 0.001) but declined by 24&#xa0;h post-Ex1 (− 5.28%, <i>p</i> = 0.003) and 24&#xa0;h post-Ex2 (-6.62%, <i>p</i> = 0.001) compared to post-Ex1 &amp; post-Ex2, respectively. NT-proBNP increased post-Ex1 (19.66%, <i>p</i> = 0.001), post-Ex2 (12.09%, <i>p</i> = 0.001) but decreased in 24&#xa0;h-Ex1 (− 20.28%, <i>p</i> = 0.001), 24&#xa0;h-Ex2 (-20.83%, <i>p</i> = 0.001) compared to post-Ex1&amp;Ex2, respectively. Following a 31.18% increase post-Ex1, a smaller 23.65% increase was observed post-Ex2 in hs-TnT levels, however, decreases of -19.57 and − 32.20% were observed 24&#xa0;h- postEx1&amp;Ex2 compared to post-Ex1&amp;Ex2, (<i>p</i> = 0.001 for all). Time to fatigue (TTF) improved post-supplementation (− 0.5%, <i>p</i> = 0.002), whereas the placebo showed no change (− 0.08%, <i>p</i> = 0.793).</p> Conclusions <p>CoQ10 supplementation significantly reduced post-exercise cardiac stress markers (GDF-15, NT-proBNP, hs-TnT) and improved TTF in athletes. These findings suggest potential associations with reduced cardiac stress responses to exercise, but further studies are required to confirm the clinical significance and long-term effects of CoQ10 supplementation on cardiovascular health in athletes.</p> Trial registration <p>not applicable.</p>

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Short-term CoQ10 supplementation reduces markers of cardiac stress in soccer players following heavy exercise: A randomized double-blind placebo-controlled trial

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  • 出版模式：

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  • 发表日期：

    2025年12月9日

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  • Mohammad Rahman Rahimi,
  • Aaron B. Morton,
  • Hadi Golpasandi,
  • Suren Hassan Salih

摘要

Background

Coenzyme Q10 (CoQ10), a vital mitochondrial antioxidant, may enhance cardiovascular recovery and delay fatigue in athletes. This double-blind, randomized, placebo-controlled trial investigated CoQ10’s effects on cardiac stress markers and exercise performance in 16 professional soccer players.

Methods

Participants received either CoQ10 (n = 8) or placebo (n = 8) for 30 days and completed exhaustive aerobic cycling tests pre- and post-supplementation. Blood samples were collected at six time points to analyze GDF-15, NT-proBNP, and hs-TnT levels.

Results

In the CoQ10 group, GDF-15 rose post-exercise (PreEx1-PostEx1: +8.84%, p = 0.003; PreEx2-PostEx2: +5.37%, p = 0.001) but declined by 24 h post-Ex1 (− 5.28%, p = 0.003) and 24 h post-Ex2 (-6.62%, p = 0.001) compared to post-Ex1 & post-Ex2, respectively. NT-proBNP increased post-Ex1 (19.66%, p = 0.001), post-Ex2 (12.09%, p = 0.001) but decreased in 24 h-Ex1 (− 20.28%, p = 0.001), 24 h-Ex2 (-20.83%, p = 0.001) compared to post-Ex1&Ex2, respectively. Following a 31.18% increase post-Ex1, a smaller 23.65% increase was observed post-Ex2 in hs-TnT levels, however, decreases of -19.57 and − 32.20% were observed 24 h- postEx1&Ex2 compared to post-Ex1&Ex2, (p = 0.001 for all). Time to fatigue (TTF) improved post-supplementation (− 0.5%, p = 0.002), whereas the placebo showed no change (− 0.08%, p = 0.793).

Conclusions

CoQ10 supplementation significantly reduced post-exercise cardiac stress markers (GDF-15, NT-proBNP, hs-TnT) and improved TTF in athletes. These findings suggest potential associations with reduced cardiac stress responses to exercise, but further studies are required to confirm the clinical significance and long-term effects of CoQ10 supplementation on cardiovascular health in athletes.

Trial registration

not applicable.