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Background <p>This study aimed to investigate the relationship between the Metabolic Score for Visceral Fat (METS-VF) and all-cause mortality among community-dwelling older adults, and to evaluate the potential mediating effect of brachial-ankle pulse wave velocity (baPWV) in this relationship.</p> Methods <p>A prospective cohort of 1,794 community-dwelling elderly Chinese (mean age 71.2) was followed for a median of 9.9 years. METS-VF and baPWV were measured at baseline. We performed Cox regression to determine hazard ratios across METS-VF quartiles, restricted cubic splines (RCS) to examine potential nonlinearity, and mediation analysis to assess the effect mediated through baPWVA.</p> Results <p>The mean age of the 1,794 participants was 71.2 years. Over a median follow-up of 9.9 years, 328 deaths were recorded. After multivariable adjustment, individuals in the highest METS-VF quartile had a significantly higher risk of mortality compared to those in the lowest quartile (hazard ratio [HR] = 2.43, 95% confidence interval [CI]: 1.46–4.06, <i>p</i> &lt; 0.001). The restricted cubic spline analysis revealed that a nonlinear dose-response relationship was observed between METS-VF and mortality (P for nonlinearity &lt; 0.001). Mediation analysis revealed that baPWV played a significant role in explaining the association between METS-VF and mortality.</p> Conclusion <p>Our study confirms the independent association between METS-VF and all-cause mortality in the community-dwelling elderly. The findings are consistent with a partial mediation effect of arterial stiffness in this relationship, providing insights into a potential underlying mechanism.</p>

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Association of metabolic score for visceral fat and risk of arterial stiffness and long-term all-cause mortality: a 10-year prospective study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月17日

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  • Yue Chen,
  • Qinzhi Cao,
  • Jin Sun,
  • Nan Zhang,
  • Shuaishuai Zhang,
  • Yan Wang,
  • Boyang Zeng,
  • Jiaojiao Qiu,
  • Guanchao Sun,
  • Bangguo Qin,
  • Man Li,
  • Bokai Cheng,
  • Zimei Chi,
  • Qiligeer Bao,
  • Shuang Cai,
  • Shuxia Wang,
  • Ping Zhu

摘要

Background

This study aimed to investigate the relationship between the Metabolic Score for Visceral Fat (METS-VF) and all-cause mortality among community-dwelling older adults, and to evaluate the potential mediating effect of brachial-ankle pulse wave velocity (baPWV) in this relationship.

Methods

A prospective cohort of 1,794 community-dwelling elderly Chinese (mean age 71.2) was followed for a median of 9.9 years. METS-VF and baPWV were measured at baseline. We performed Cox regression to determine hazard ratios across METS-VF quartiles, restricted cubic splines (RCS) to examine potential nonlinearity, and mediation analysis to assess the effect mediated through baPWVA.

Results

The mean age of the 1,794 participants was 71.2 years. Over a median follow-up of 9.9 years, 328 deaths were recorded. After multivariable adjustment, individuals in the highest METS-VF quartile had a significantly higher risk of mortality compared to those in the lowest quartile (hazard ratio [HR] = 2.43, 95% confidence interval [CI]: 1.46–4.06, p < 0.001). The restricted cubic spline analysis revealed that a nonlinear dose-response relationship was observed between METS-VF and mortality (P for nonlinearity < 0.001). Mediation analysis revealed that baPWV played a significant role in explaining the association between METS-VF and mortality.

Conclusion

Our study confirms the independent association between METS-VF and all-cause mortality in the community-dwelling elderly. The findings are consistent with a partial mediation effect of arterial stiffness in this relationship, providing insights into a potential underlying mechanism.