Scholarlink

Objective <p>Recent evidence suggests a strong association between triglyceride glucose-a body shape index (TyG-ABSI) and cardiovascular mortality. However, the association between TyG-ABSI and incident stroke has not been explored. Our study utilized a prospective cohort design to explore the potential association between TyG-ABSI and incident stroke within a Chinese population.</p> Methods <p>A total of 8,715 subjects from the China Health and Retirement Longitudinal Study were included in this analysis, categorized into stroke (<i>n</i> = 805) and non-stroke (<i>n</i> = 7,910) groups. To assess the association between TyG-ABSI and incident stroke, this study employed Cox proportional hazards regression, restricted cubic spline models, subgroup analyses, and sensitivity analyses.</p> Results <p>The mean age of participants was significantly higher in the stroke group (61.26 ± 8.42 years) compared to the non-stroke group (59.14 ± 9.27 years). Multivariate analysis revealed that higher TyG-ABSI was significantly associated with increased stroke risk, with an HR of 1.22 (95% CI: 1.09–1.37, <i>P</i> = 0.0004). Notably, this association between TyG-ABSI and incident stroke was non-linear, and a significant inflection point was identified at a TyG-ABSI of 6.42. The HR to the left and right of this inflection point were 2.44 (95%CI: 1.19–5.02, <i>P</i> = 0.0151) and 1.16 (95%CI: 1.02–1.31, <i>P</i> = 0.0239), respectively. Subgroup and sensitivity analyses further validated the robustness of the association between TyG-ABSI and incident stroke.</p> Conclusion <p>Our analysis revealed a non-linear positive association between TyG-ABSI and incident stroke. These findings emphasize the necessity of incorporating TyG-ABSI monitoring into clinical practice to identify individuals at greater risk for stroke.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Non-linear relationship between the triglyceride glucose-a body shape index and stroke risk: a prospective cohort study from the China health and retirement longitudinal study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月4日

查看全文
  • Dongpo He,
  • Zhenzhen Fan,
  • Xintao Zhang,
  • Changchun Cao,
  • Yong Han,
  • Haofei Hu,
  • Xiaodan Zheng

摘要

Objective

Recent evidence suggests a strong association between triglyceride glucose-a body shape index (TyG-ABSI) and cardiovascular mortality. However, the association between TyG-ABSI and incident stroke has not been explored. Our study utilized a prospective cohort design to explore the potential association between TyG-ABSI and incident stroke within a Chinese population.

Methods

A total of 8,715 subjects from the China Health and Retirement Longitudinal Study were included in this analysis, categorized into stroke (n = 805) and non-stroke (n = 7,910) groups. To assess the association between TyG-ABSI and incident stroke, this study employed Cox proportional hazards regression, restricted cubic spline models, subgroup analyses, and sensitivity analyses.

Results

The mean age of participants was significantly higher in the stroke group (61.26 ± 8.42 years) compared to the non-stroke group (59.14 ± 9.27 years). Multivariate analysis revealed that higher TyG-ABSI was significantly associated with increased stroke risk, with an HR of 1.22 (95% CI: 1.09–1.37, P = 0.0004). Notably, this association between TyG-ABSI and incident stroke was non-linear, and a significant inflection point was identified at a TyG-ABSI of 6.42. The HR to the left and right of this inflection point were 2.44 (95%CI: 1.19–5.02, P = 0.0151) and 1.16 (95%CI: 1.02–1.31, P = 0.0239), respectively. Subgroup and sensitivity analyses further validated the robustness of the association between TyG-ABSI and incident stroke.

Conclusion

Our analysis revealed a non-linear positive association between TyG-ABSI and incident stroke. These findings emphasize the necessity of incorporating TyG-ABSI monitoring into clinical practice to identify individuals at greater risk for stroke.