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Background <p>Left ventricular (LV) concentric hypertrophy is common in diabetes patients, presenting as a relatively small LV size. However, studies have shown that a small LV size can also occur in prediabetic conditions without ventricular hypertrophy. We used data from the UK Biobank Cardiovascular Magnetic Resonance Substudy to assess whether a small LV size independently predicts incident type 2 diabetes.</p> Methods and results <p>Small LV size was defined using indexed left ventricular end-diastolic volume (iLVEDV) values (&lt; 56 mL/m² for females and &lt; 57 mL/m² for males). The risk of small LV size for incident type 2 diabetes was assessed using adjusted Cox proportional hazards models. The non-linear relationship between iLVEDV and diabetes risk was evaluated using restricted cubic splines. This study included 35,422 participants, with an average age of 64 years, of whom 53.2% were females. Among the 35,422 participants, 947 (2.7%) had small LV size. During a median follow-up of 698 days, 304 cases of incident type 2 diabetes were recorded. Those with small LV size showed a significant association with increased risk of incident type 2 diabetes (adjusted hazard ratio [HR], 2.36; 95% CI, 1.56–3.57). Subgroup analysis consistently supported this relationship across age, sex, hypertension, obesity, and genetic risk for type 2 diabetes. An L-shaped relationship between iLVEDV and diabetes risk was also observed.</p> Conclusions <p>Small LV size is an independent predictor of incident type 2 diabetes, with a smaller LV size correlating with a higher risk of developing the condition, warranting further investigation.</p> Graphical Abstract <p></p>

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Small left ventricular size as a predictor for incident type 2 diabetes: insights from the UK biobank cardiovascular magnetic resonance substudy

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月3日

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  • Gaifeng Hu,
  • Xiaodong Peng,
  • Liu He,
  • Zixu Zhao,
  • Caihua Sang,
  • Jianzeng Dong,
  • Changsheng Ma

摘要

Background

Left ventricular (LV) concentric hypertrophy is common in diabetes patients, presenting as a relatively small LV size. However, studies have shown that a small LV size can also occur in prediabetic conditions without ventricular hypertrophy. We used data from the UK Biobank Cardiovascular Magnetic Resonance Substudy to assess whether a small LV size independently predicts incident type 2 diabetes.

Methods and results

Small LV size was defined using indexed left ventricular end-diastolic volume (iLVEDV) values (< 56 mL/m² for females and < 57 mL/m² for males). The risk of small LV size for incident type 2 diabetes was assessed using adjusted Cox proportional hazards models. The non-linear relationship between iLVEDV and diabetes risk was evaluated using restricted cubic splines. This study included 35,422 participants, with an average age of 64 years, of whom 53.2% were females. Among the 35,422 participants, 947 (2.7%) had small LV size. During a median follow-up of 698 days, 304 cases of incident type 2 diabetes were recorded. Those with small LV size showed a significant association with increased risk of incident type 2 diabetes (adjusted hazard ratio [HR], 2.36; 95% CI, 1.56–3.57). Subgroup analysis consistently supported this relationship across age, sex, hypertension, obesity, and genetic risk for type 2 diabetes. An L-shaped relationship between iLVEDV and diabetes risk was also observed.

Conclusions

Small LV size is an independent predictor of incident type 2 diabetes, with a smaller LV size correlating with a higher risk of developing the condition, warranting further investigation.

Graphical Abstract