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Background <p>Diabetes is often associated with dyslipidemia, increasing the risk of cardiovascular complications. Studies have shown that Vitamin E, as a potent antioxidant, may improve serum lipid profile by reducing oxidative stress and inflammation. However, findings on its effects on diabetic patients remain inconsistent. To address this gap, this meta-analysis aims to evaluate the impact of vitamin E on serum lipid parameters in individuals with diabetes.</p> Methods <p>A search was conducted on databases from inception to June 2025 to identify relevant randomized controlled trials (RCTs). Pooled effect sizes were estimated using weighted mean differences (WMDs) with 95% confidence intervals (CIs), applying a random-effects model. All statistical analyses were performed using STATA (V. 11.2).</p> Results <p>The pooled analysis of 28 RCTs found that overall vitamin E administration in diabetic patients significantly reduced total cholesterol (TC) (WMD: −&#xa0;5.20&#xa0;mg/dL, 95% CI: [−&#xa0;7.60, −&#xa0;2.80], <i>p</i> &lt; 0.001) and low-density lipoprotein cholesterol (LDL-C) (WMD: −&#xa0;4.21&#xa0;mg/dL, 95% CI: [−&#xa0;7.32, −&#xa0;1.09], <i>p</i> = 0.008). While no significant change was observed in triglyceride (TG) (WMD: −&#xa0;6.19&#xa0;mg/dL, 95% CI: [−&#xa0;13.13, 0.75],<i> p</i> = 0.081) and high-density lipoprotein cholesterol (HDL-C) serum levels (WMD: 0.57&#xa0;mg/dL, 95%CI: [−&#xa0;0.11, 1.24], <i>p</i> = 0.99). Subgroup analysis showed that vitamin E reduced TG with longer durations, lowered TC and LDL-C in participants with high baseline levels, higher doses, or longer interventions, and increased HDL-C only in studies lasting over 8&#xa0;weeks. Linear regression analysis found no significant associations between vitamin E dose or duration and serum lipids. In contrast, non-linear dose–response analysis showed a significant inverse relationship between vitamin E dose and TC levels.</p> Conclusion <p>Vitamin E administration may improve lipid profiles in diabetic patients, with significant reductions in TC and LDL-C, while effects on TG and HDL-C were not statistically significant but showed potential clinical relevance. Subgroup analysis highlighted greater benefits with higher doses (&gt; 400&#xa0;IU/day) and longer intervention durations (&gt; 8&#xa0;weeks), particularly in individuals with elevated baseline lipid levels. Further large-scale studies are needed to confirm these findings and establish optimal dosing strategies for clinical application.</p>

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Effects of vitamin E administration on serum lipid profile in diabetic patients: a grade-assessed systematic review and dose–response meta-analysis of RCTs

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月18日

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  • Mehdi Karimi,
  • Mohammad Amin Karimi,
  • Farzad Fayedeh,
  • Fatemeh Ziyafati Kafi,
  • Kimia Kazemi,
  • Sharareh Jahangiri,
  • Omid Asbaghi

摘要

Background

Diabetes is often associated with dyslipidemia, increasing the risk of cardiovascular complications. Studies have shown that Vitamin E, as a potent antioxidant, may improve serum lipid profile by reducing oxidative stress and inflammation. However, findings on its effects on diabetic patients remain inconsistent. To address this gap, this meta-analysis aims to evaluate the impact of vitamin E on serum lipid parameters in individuals with diabetes.

Methods

A search was conducted on databases from inception to June 2025 to identify relevant randomized controlled trials (RCTs). Pooled effect sizes were estimated using weighted mean differences (WMDs) with 95% confidence intervals (CIs), applying a random-effects model. All statistical analyses were performed using STATA (V. 11.2).

Results

The pooled analysis of 28 RCTs found that overall vitamin E administration in diabetic patients significantly reduced total cholesterol (TC) (WMD: − 5.20 mg/dL, 95% CI: [− 7.60, − 2.80], p < 0.001) and low-density lipoprotein cholesterol (LDL-C) (WMD: − 4.21 mg/dL, 95% CI: [− 7.32, − 1.09], p = 0.008). While no significant change was observed in triglyceride (TG) (WMD: − 6.19 mg/dL, 95% CI: [− 13.13, 0.75], p = 0.081) and high-density lipoprotein cholesterol (HDL-C) serum levels (WMD: 0.57 mg/dL, 95%CI: [− 0.11, 1.24], p = 0.99). Subgroup analysis showed that vitamin E reduced TG with longer durations, lowered TC and LDL-C in participants with high baseline levels, higher doses, or longer interventions, and increased HDL-C only in studies lasting over 8 weeks. Linear regression analysis found no significant associations between vitamin E dose or duration and serum lipids. In contrast, non-linear dose–response analysis showed a significant inverse relationship between vitamin E dose and TC levels.

Conclusion

Vitamin E administration may improve lipid profiles in diabetic patients, with significant reductions in TC and LDL-C, while effects on TG and HDL-C were not statistically significant but showed potential clinical relevance. Subgroup analysis highlighted greater benefits with higher doses (> 400 IU/day) and longer intervention durations (> 8 weeks), particularly in individuals with elevated baseline lipid levels. Further large-scale studies are needed to confirm these findings and establish optimal dosing strategies for clinical application.