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Objectives <p>we aimed to evaluate the association of interleukin-1β (<i>IL-1β</i>) gene single nucleotide polymorphisms (SNPs) and its interaction with smoking status on diabetic nephropathy (DN) risk in a Chinese Han population.</p> Methods <p>The Hardy-Weinberg equilibrium (HWE) was tested by using SNPStats (<a href="https://www.snpstats.net/start.htm">https://www.snpstats.net/start.htm</a>), which was also used for testing the relationship between four SNPs and DN risk and haplotype analysis. The SNP- SNP and gene- smoking interaction were verified by using generalized multifactor dimensionality reduction (GMDR) model.</p> Results <p>Logistic regression suggested that the DN risks of participants with rs16944- G allele were significantly higher than those with AA genotype, adjusted OR (95%CI) = 1.62 (1.24–2.01) for AG <i>versus</i> AA, 1.41 (0.75–2.12) for GG <i>versus</i> AA. Additionally, we also found that participants with rs3917356- T allele had an obviously higher DN risk than those with CC genotype, adjusted OR (95%CI) = 1.75 (1.34–2.19) for CT <i>versus</i> CC, 1.87 (1.23–2.54) for TT <i>versus</i> CC. GMDR model found a significant two-locus model (<i>P</i> = 0.011) including rs16944 and smoking. Compared with non- smokers with rs16944- AA genotype, smokers with rs1225404 AG or GG genotype had the highest DN risk after covariates adjustment, OR (95%CI) was 3.04 (1.98–4.12). We also found a haplotype containing rs1143634- T and rs3917356- T was associated with higher DN risk.</p> Conclusions <p>we found that the rs16944- G and rs3917356- T allele, interaction between rs16944 and smoking, haplotype containing rs1143634- T and rs3917356- T were all associated with increased DN risk.</p>

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Association of the interaction between interleukin-1β gene polymorphism and smoking status with the diabetic nephropathy risk in a Chinese Han population

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  • 发表日期：

    2025年3月25日

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  • Tianyue Xie,
  • Zhuqi Tang

摘要

Objectives

we aimed to evaluate the association of interleukin-1β (IL-1β) gene single nucleotide polymorphisms (SNPs) and its interaction with smoking status on diabetic nephropathy (DN) risk in a Chinese Han population.

Methods

The Hardy-Weinberg equilibrium (HWE) was tested by using SNPStats (https://www.snpstats.net/start.htm), which was also used for testing the relationship between four SNPs and DN risk and haplotype analysis. The SNP- SNP and gene- smoking interaction were verified by using generalized multifactor dimensionality reduction (GMDR) model.

Results

Logistic regression suggested that the DN risks of participants with rs16944- G allele were significantly higher than those with AA genotype, adjusted OR (95%CI) = 1.62 (1.24–2.01) for AG versus AA, 1.41 (0.75–2.12) for GG versus AA. Additionally, we also found that participants with rs3917356- T allele had an obviously higher DN risk than those with CC genotype, adjusted OR (95%CI) = 1.75 (1.34–2.19) for CT versus CC, 1.87 (1.23–2.54) for TT versus CC. GMDR model found a significant two-locus model (P = 0.011) including rs16944 and smoking. Compared with non- smokers with rs16944- AA genotype, smokers with rs1225404 AG or GG genotype had the highest DN risk after covariates adjustment, OR (95%CI) was 3.04 (1.98–4.12). We also found a haplotype containing rs1143634- T and rs3917356- T was associated with higher DN risk.

Conclusions

we found that the rs16944- G and rs3917356- T allele, interaction between rs16944 and smoking, haplotype containing rs1143634- T and rs3917356- T were all associated with increased DN risk.