Unveiling myocardial microstructure shifts: exploring the impact of diabetes in stable CAD patients through CMR T1 mapping

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2024年7月9日

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Gustavo André Boeing Boros,
Whady Hueb,
Paulo Cury Rezende,
Carlos Eduardo Rochitte,
Cesar Higa Nomura,
Eduardo Gomes Lima,
Matheus de Oliveira Laterza Ribeiro,
Anderson Roberto Dallazen,
Rosa Maria Rahmi Garcia,
Jose Antonio Franchini Ramires,
Roberto Kalil-Filho

摘要

Background

This study investigates myocardial structural changes in stable coronary artery disease (CAD) patients with type 2 diabetes (T2D) using cardiac magnetic resonance (CMR) strain and T1 mapping.

Methods

A total of 155 stable CAD patients underwent CMR examination, including left ventricular (LV) morphology and function assessment, late gadolinium enhancement (LGE), and feature tracking (CMR-FT) for LV global longitudinal, circumferential, and radial strain. T1 mapping with extracellular volume (ECV) evaluation was also performed.

Results

Among the enrolled patients, 67 had T2D. Diabetic patients exhibited impaired LV strain and higher ECV compared to non-diabetics. Multivariate analysis identified T2D as an independent predictor of increased ECV and decreased strain.

Conclusions

CMR-based strain and T1 mapping highlighted impaired myocardial contractility, elevated ECV, and potential interstitial fibrosis in diabetic patients with stable CAD. This suggests a significant impact of diabetes on myocardial health beyond CAD, emphasizing the importance of a comprehensive assessment in these individuals.

Trial registration

http://www.controlled-trials.com/ISRCTN09454308