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Background <p>Patients with rheumatoid arthritis (RA) are at a higher risk for sarcopenia than the general population. Exercise therapy can improve muscle strength in older adults; however, its efficacy in older patients with RA has not been fully established. This study aimed to evaluate the efficacy of a personalized exercise program on physical function in older patients with RA at high risk for sarcopenia.</p> Methods <p>A single-centre, parallel-group, two-arm, superiority randomized controlled trial was conducted in patients with RA aged 60–85 years who were at risk of sarcopenia. The intervention group (<i>n</i> = 69) underwent a 16-week personalized exercise program in addition to nutritional guidance and standard care, whereas the control group (<i>n</i> = 65) received only nutritional guidance and standard care. The primary outcome was the change in the total Short Physical Performance Battery (SPPB) scores from baseline to week 16.</p> Results <p>A total of 140 patients were randomized. Of these, 134 initiated the assigned intervention. There was a 0.2-point difference in SPPB total score from baseline to week 16 between the intervention group (+ 0.4 points) and the control group (+ 0.2 points); 95% confidence interval: -0.1 to 0.5; <i>p</i> = 0.206. Regarding the secondary outcomes at week 16, there was a tendency for improvement in the chair-stand test, grip strength, and the mental component score.</p> Conclusion <p>The 16-week personalized exercise therapy did not improve the total SPPB scores. However, the intervention may improve standing ability, grip strength, and mental health-related quality of life in older patients with RA at high risk of sarcopenia.</p> Trial registration <p>This study was registered with UMINCTR (trial number: UMIN000044930).</p>

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Effects of a personalized exercise program on physical function in older patients with rheumatoid arthritis at high risk of sarcopenia: results of a randomized controlled trial

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月6日

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  • Mie Torii,
  • Akira Onishi,
  • Ryuji Uozumi,
  • Yu Hidaka,
  • Hideo Onizawa,
  • Takayuki Fujii,
  • Koichi Murata,
  • Kosaku Murakami,
  • Masao Tanaka,
  • Yohei Oshima,
  • Hiroki Tanaka,
  • Yuki Urai,
  • Kyosuke Tanigawa,
  • Hiroyuki Yoshitomi,
  • Hideaki Tsuji,
  • Mirei Shirakashi,
  • Ryosuke Hiwa,
  • Ran Nakashima,
  • Kazuko Nin,
  • Ayae Kinoshita,
  • Shuichi Matsuda,
  • Akio Morinobu,
  • Hidenori Arai,
  • Motomu Hashimoto

摘要

Background

Patients with rheumatoid arthritis (RA) are at a higher risk for sarcopenia than the general population. Exercise therapy can improve muscle strength in older adults; however, its efficacy in older patients with RA has not been fully established. This study aimed to evaluate the efficacy of a personalized exercise program on physical function in older patients with RA at high risk for sarcopenia.

Methods

A single-centre, parallel-group, two-arm, superiority randomized controlled trial was conducted in patients with RA aged 60–85 years who were at risk of sarcopenia. The intervention group (n = 69) underwent a 16-week personalized exercise program in addition to nutritional guidance and standard care, whereas the control group (n = 65) received only nutritional guidance and standard care. The primary outcome was the change in the total Short Physical Performance Battery (SPPB) scores from baseline to week 16.

Results

A total of 140 patients were randomized. Of these, 134 initiated the assigned intervention. There was a 0.2-point difference in SPPB total score from baseline to week 16 between the intervention group (+ 0.4 points) and the control group (+ 0.2 points); 95% confidence interval: -0.1 to 0.5; p = 0.206. Regarding the secondary outcomes at week 16, there was a tendency for improvement in the chair-stand test, grip strength, and the mental component score.

Conclusion

The 16-week personalized exercise therapy did not improve the total SPPB scores. However, the intervention may improve standing ability, grip strength, and mental health-related quality of life in older patients with RA at high risk of sarcopenia.

Trial registration

This study was registered with UMINCTR (trial number: UMIN000044930).