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Background <p>Four studies investigated the efficacy of fluralaner/moxidectin/pyrantel chewable tablets (Bravecto® TriUNO) in preventing and treating canine angiostrongylosis; one study also included a formulation of fluralaner/milbemycin oxime.</p> Methods <p>Studies included eight or 10 dogs/group. In Studies 1 and 2 (prevention), dogs inoculated with third-stage larvae of <i>Angiostrongylus vasorum</i> on day − 31 or − 28 were randomized to groups by sex and body weight; in Studies 3 and 4 (treatment) by faecal first-stage larvae counts at approximately 8&#xa0;weeks post-inoculation (PI). All studies included an untreated control group (CG). Study 1 included three groups treated with formulations of moxidectin/fluralaner/pyrantel; minimum moxidectin doses 0.0125, 0.025 or 0.055&#xa0;mg/kg. The formulation with moxidectin at 0.025&#xa0;mg/kg, 99.0% effective in preventing establishment of infection, was adopted as the investigational veterinary product (IVP) for the following studies. Study 2 included a group treated with either the IVP or a combination of fluralaner (10&#xa0;mg/kg) with milbemycin oxime (0.75&#xa0;mg/kg) (IVP-2). In all studies, the IVP was administered once on day 0; in Study 2, IVP-2 was administered on days 0, 31, 62 and 93. In Study 1, efficacy was determined by reductions in geometric mean necropsy worm counts approximately 33&#xa0;days post-treatment versus mean CG counts, in the other studies by reductions in mean faecal L1 counts. Study 2 assessed pulmonary changes via thoracic computed tomography. Respiratory signs and serological antibody responses were monitored.</p> Results <p>In Study 1, all moxidectin doses exceeded 90% efficacy. In Study 2, IVP efficacy (one treatment) at 62&#xa0;days was 100.0%; IVP-2 (four treatments) efficacy was 99.8% at 124&#xa0;days. Respiratory signs were absent or lower in IVP-treated than CG dogs. In Studies 3 and 4, IVP efficacy was 100% by 3 and 4&#xa0;weeks post-treatment, respectively. In all studies, lungworm count reductions in the IVP groups were statistically significant (<i>P</i> &lt; 0.0001) versus the CG. Serology confirmed <i>A. vasorum</i> infections in all control and IVP-2-treated dogs, and absence of infections in IVP-treated dogs. Treatments were well tolerated.</p> Conclusions <p>A single treatment with Bravecto TriUNO is highly effective in preventing angiostrongylosis and eliminating established <i>A. vasorum</i> infections. Infection-related lung pathology was reduced in treated dogs.</p> Graphical abstract <p></p>

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Efficacy of a single oral administration of a formulation of fluralaner, moxidectin and pyrantel (BRAVECTO® TriUNO) in dogs for the treatment and prevention of angiostrongylosis

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  • 发表日期：

    2026年7月24日

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  • Nadja Rohdich,
  • Rafael Chiummo,
  • Eva Zschiesche,
  • Marie-Kristin Raulf,
  • Anna Schwarz,
  • Anne McLoughlin,
  • Manuela Schnyder,
  • Jenny Schulte Bocholt,
  • Kristina Merhof,
  • Manon Mikić,
  • Christina Strube,
  • Lea Heinau

摘要

Background

Four studies investigated the efficacy of fluralaner/moxidectin/pyrantel chewable tablets (Bravecto® TriUNO) in preventing and treating canine angiostrongylosis; one study also included a formulation of fluralaner/milbemycin oxime.

Methods

Studies included eight or 10 dogs/group. In Studies 1 and 2 (prevention), dogs inoculated with third-stage larvae of Angiostrongylus vasorum on day − 31 or − 28 were randomized to groups by sex and body weight; in Studies 3 and 4 (treatment) by faecal first-stage larvae counts at approximately 8 weeks post-inoculation (PI). All studies included an untreated control group (CG). Study 1 included three groups treated with formulations of moxidectin/fluralaner/pyrantel; minimum moxidectin doses 0.0125, 0.025 or 0.055 mg/kg. The formulation with moxidectin at 0.025 mg/kg, 99.0% effective in preventing establishment of infection, was adopted as the investigational veterinary product (IVP) for the following studies. Study 2 included a group treated with either the IVP or a combination of fluralaner (10 mg/kg) with milbemycin oxime (0.75 mg/kg) (IVP-2). In all studies, the IVP was administered once on day 0; in Study 2, IVP-2 was administered on days 0, 31, 62 and 93. In Study 1, efficacy was determined by reductions in geometric mean necropsy worm counts approximately 33 days post-treatment versus mean CG counts, in the other studies by reductions in mean faecal L1 counts. Study 2 assessed pulmonary changes via thoracic computed tomography. Respiratory signs and serological antibody responses were monitored.

Results

In Study 1, all moxidectin doses exceeded 90% efficacy. In Study 2, IVP efficacy (one treatment) at 62 days was 100.0%; IVP-2 (four treatments) efficacy was 99.8% at 124 days. Respiratory signs were absent or lower in IVP-treated than CG dogs. In Studies 3 and 4, IVP efficacy was 100% by 3 and 4 weeks post-treatment, respectively. In all studies, lungworm count reductions in the IVP groups were statistically significant (P < 0.0001) versus the CG. Serology confirmed A. vasorum infections in all control and IVP-2-treated dogs, and absence of infections in IVP-treated dogs. Treatments were well tolerated.

Conclusions

A single treatment with Bravecto TriUNO is highly effective in preventing angiostrongylosis and eliminating established A. vasorum infections. Infection-related lung pathology was reduced in treated dogs.

Graphical abstract