Efficacy of azithromycin combined with compounded atovaquone in treating babesiosis in giant pandas

期刊论文
出版模式：

开放获取
发表日期：

2024年12月23日

查看全文

Rui Ma,
Chanjuan Yue,
Jiang Gu,
Wei Wu,
Rong Hou,
Wenjun Huang,
Bi Li,
Fei Xue,
Chong Huang,
Wenlei Bi,
Jiabin Liu,
Xiang Yu,
Zusheng Li,
Wanjing Yang,
Mingxia Fu,
Hong Yang,
Dunwu Qi

摘要

Background

Babesia is a tick-borne protozoan blood parasite that can cause hemolytic anemia, thrombocytopenia, lethargy and splenomegaly in giant pandas.

Methods

We evaluated the efficacy and safety profile of a therapeutic regimen combining atovaquone and zithromycin in the context of babesiosis in giant pandas that have been naturally infected. The examined pandas underwent clinical and laboratory analyses, including hematology, biochemistry and thyroid hormone profiles. Upon diagnosis, the giant pandas were administered a compounded treatment consisting of atovaquone oral suspension (15 mg/kg, PO, q8 h), azithromycin tablets (10 mg/kg, PO, q24 h) and Enteral Nutritional Suspension (TPF) as a fat-rich supplement (0.5 ml/kg, PO, q8 h) for a 10-day period.

Results

The combination treatment increased the red blood cell count, hemoglobin levels and hematocrit in the pandas within a short period, while also reducing parasite levels below the PCR detection threshold.

Conclusions

Our study suggested that atovaquone and azithromycin combination therapy is highly effective for emergency treatment of Babesia sp. infection in giant pandas.

Graphical Abstract