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<p>In this work, a new, sensitive, precise, accurate, and eco-friendly spectrofluorometric method for the detection of Bosentan in human plasma and pharmaceutical dosage form was developed, using silver nanoparticles (AgNPs) as an efficient fluorescence sensing probe. The general concept used in this approach is based on collisional quenching of AgNPs fluorescence intensity. Over the concentration range of 0.02 to 0.12&#xa0;µg/mL, the quenching impact of BOS on AgNPs increased as its concentration increased. The suggested method’s greenness was assessed using two metric systems: the Analytical Eco-scale (AES) with a score of 80 and the AGREE greenness assessment tool with a score of 0.68.</p> Graphical Abstract <p></p>

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Silver nanoparticles-based green fluorescent probe for determination of Bosentan in pharmaceutical formulation and spiked plasma samples

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月21日

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  • Yossra A. Trabik,
  • Rehem A. Ismail,
  • Miriam F. Ayad,
  • Lobna A. Hussein

摘要

In this work, a new, sensitive, precise, accurate, and eco-friendly spectrofluorometric method for the detection of Bosentan in human plasma and pharmaceutical dosage form was developed, using silver nanoparticles (AgNPs) as an efficient fluorescence sensing probe. The general concept used in this approach is based on collisional quenching of AgNPs fluorescence intensity. Over the concentration range of 0.02 to 0.12 µg/mL, the quenching impact of BOS on AgNPs increased as its concentration increased. The suggested method’s greenness was assessed using two metric systems: the Analytical Eco-scale (AES) with a score of 80 and the AGREE greenness assessment tool with a score of 0.68.

Graphical Abstract