Scholarlink

<p>Ionic liquids (ILs) have gained significant attention among material scientists for their versatile properties. Amino acid-based ionic liquids (AAILs) have the potential to be tailored for desired physicochemical properties due to their structural adaptability and unique attributes. Twenty-four distinct ILs were synthesized, containing multifunctional cations viz<i>.</i> 1-octyl pyridinium, 1-octyl-3-methylimidazolium, 1,3-dioctylimidazolium, Di-octyldi-butylammonium, Tetraoctylphosphonium, <i>N</i>, <i>N</i>, <i>N</i>', <i>N</i>'-Tetrakis-(2-hydroxyethyl)dioctyldiammonium, 1H-1,2,3-triazole, and 1-octyl-1,8-diazabicyclo(5.4.0)undec-7-enium, each with varied chain lengths. Whereas, bromide, glycinate, and leucinate were incorporated as counter-anionic species. These distinct ILs were characterized by FT-IR, <sup>1</sup>H, and <sup>13</sup>C-NMR spectroscopies and were systematically evaluated for anti-bacterial efficacy by agar well diffusion method against six potent bacterial strains. Both gram-positive as well as gram-negative types, namely <i>Shigella dysenteria, Shigella boyydii, Staphylococcus aureus, Carbapenem-resistant Enterobacter baumannii, Escherichia coli,</i> and <i>Klebsiella pneumonia</i> were tested. Remarkably strong antibacterial performance was observed across most of the synthesized ILs, particularly notable against gram-negative strains, signifying their potential as antibacterial agents. The good antibacterial performance of ILs was also validated by molecular docking, and a good agreement was found between computational and experimental studies. These findings open new avenues for the development of effective antibacterial agents based on ILs in infection control for individuals with disabilities.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

l-Glycine and l-leucine derived multifunctional ionic liquids for potential antibacterial applications: in-vitro and in-silico studies

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月21日

查看全文
  • Amina Arshad,
  • Hira Akram,
  • Habib Ullah,
  • Saadia Andleeb,
  • Muhammad Shafiq,
  • Zaheer Ul-Haq,
  • Rawaiz Khan,
  • Ali Bahadar,
  • Azhar Mahmood,
  • Mudassir Iqbal

摘要

Ionic liquids (ILs) have gained significant attention among material scientists for their versatile properties. Amino acid-based ionic liquids (AAILs) have the potential to be tailored for desired physicochemical properties due to their structural adaptability and unique attributes. Twenty-four distinct ILs were synthesized, containing multifunctional cations viz. 1-octyl pyridinium, 1-octyl-3-methylimidazolium, 1,3-dioctylimidazolium, Di-octyldi-butylammonium, Tetraoctylphosphonium, N, N, N', N'-Tetrakis-(2-hydroxyethyl)dioctyldiammonium, 1H-1,2,3-triazole, and 1-octyl-1,8-diazabicyclo(5.4.0)undec-7-enium, each with varied chain lengths. Whereas, bromide, glycinate, and leucinate were incorporated as counter-anionic species. These distinct ILs were characterized by FT-IR, 1H, and 13C-NMR spectroscopies and were systematically evaluated for anti-bacterial efficacy by agar well diffusion method against six potent bacterial strains. Both gram-positive as well as gram-negative types, namely Shigella dysenteria, Shigella boyydii, Staphylococcus aureus, Carbapenem-resistant Enterobacter baumannii, Escherichia coli, and Klebsiella pneumonia were tested. Remarkably strong antibacterial performance was observed across most of the synthesized ILs, particularly notable against gram-negative strains, signifying their potential as antibacterial agents. The good antibacterial performance of ILs was also validated by molecular docking, and a good agreement was found between computational and experimental studies. These findings open new avenues for the development of effective antibacterial agents based on ILs in infection control for individuals with disabilities.