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Background <p>Antimicrobial resistance poses a growing threat to effective infection treatment, while imbalances in ascorbic acid (AA) levels are linked to various health issues. Nanotechnology offers innovative solutions, with carbon dot-based nanocomposites emerging as promising materials for both antimicrobial applications and sensitive detection of biomolecules. This study aimed to synthesize nitrogen-doped carbon dots (NCDs), copper oxide nanoparticles (CuO NPs), and their nanocomposites (CuO-NCDs), and to evaluate their electrochemical sensing of AA and antimicrobial activity.</p> Methods <p>NCDs were prepared via a hydrothermal treatment of citric acid and urea, and CuO NPs by precipitation of copper nitrate. Characterization by Ultraviolet–Visible (UV–Vis) spectroscopy, Fourier Transform Infrared (FT-IR) spectroscopy, X-ray Diffraction (XRD), and Scanning Electron Microscopy (SEM) confirmed their optical properties, functional groups, crystallinity, and morphology.</p> Results <p>The CuO-NCD nanocomposite exhibited enhanced optical absorption with a reduced energy band gap (2.6&#xa0;eV) compared to individual components. Electrochemical tests revealed a detection limit of 2.56 µM for AA and increased electrode surface area, indicating improved sensitivity and selectivity. Antimicrobial assays showed significant activity against <i>Staphylococcus aureus</i>, with a 24&#xa0;mm inhibition zone at 200&#xa0;mg/mL after 24&#xa0;h.</p> Conclusions <p>These results demonstrate that CuO-NCD nanocomposites hold potential as dual-function materials for effective AA detection and combating microbial infections.</p>

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Dual-functional nitrogen-doped carbon dot/copper oxide nanocomposites for electrochemical sensing of ascorbic acid and antimicrobial applications

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月5日

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  • Zerfu Haile Robi,
  • Dugasa Jabesa Nemera,
  • Tekileab Engida Gebremichael,
  • Guta Gonfa Muleta

摘要

Background

Antimicrobial resistance poses a growing threat to effective infection treatment, while imbalances in ascorbic acid (AA) levels are linked to various health issues. Nanotechnology offers innovative solutions, with carbon dot-based nanocomposites emerging as promising materials for both antimicrobial applications and sensitive detection of biomolecules. This study aimed to synthesize nitrogen-doped carbon dots (NCDs), copper oxide nanoparticles (CuO NPs), and their nanocomposites (CuO-NCDs), and to evaluate their electrochemical sensing of AA and antimicrobial activity.

Methods

NCDs were prepared via a hydrothermal treatment of citric acid and urea, and CuO NPs by precipitation of copper nitrate. Characterization by Ultraviolet–Visible (UV–Vis) spectroscopy, Fourier Transform Infrared (FT-IR) spectroscopy, X-ray Diffraction (XRD), and Scanning Electron Microscopy (SEM) confirmed their optical properties, functional groups, crystallinity, and morphology.

Results

The CuO-NCD nanocomposite exhibited enhanced optical absorption with a reduced energy band gap (2.6 eV) compared to individual components. Electrochemical tests revealed a detection limit of 2.56 µM for AA and increased electrode surface area, indicating improved sensitivity and selectivity. Antimicrobial assays showed significant activity against Staphylococcus aureus, with a 24 mm inhibition zone at 200 mg/mL after 24 h.

Conclusions

These results demonstrate that CuO-NCD nanocomposites hold potential as dual-function materials for effective AA detection and combating microbial infections.