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<p><i>N</i>-aryl amides hold significant importance in organic chemistry due to their widespread presence in pharmaceuticals, agrochemicals, and various bioactive compounds. As a result, catalysts and preparation methodologies for amide derivatives have long been a target of active investigation of interest. In the current work, a simple and accessible route was adopted for preparation of a magnetic catalyst [Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub>-DHB/DI(S-NH)-Pd (0)] and then its catalysis in three-component amide synthesis via carbonylation reaction between aryl iodides and amines was examined. In experiments, its efficiency in producing a range of amides with high yields in a short and under mild conditions was unequivocally confirmed, and its efficiency in producing a range of amides with high yields in a short and under mild conditions was confirmed unequivocally through experiments. High yields of the desired compound ease in catalyst separation, high reusability of catalysts, mild reaction conditions, ease in accommodation of a range of substrates, and a thorough analysis for determination of the catalyst and produced compounds for characterization and purification have been taken as key features of this work.</p> Graphical Abstract <p></p>

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Fe3O4@SiO2-DHB/DI(S-NH)-Pd(0) nanocomposite: a novel, efficient, and reusable heterogeneous catalyst for carbonylative preparation of N-aryl amides

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  • 发表日期：

    2025年3月15日

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  • Ahmed M. H. Abudken,
  • Lina Saadi,
  • Radwan Ali,
  • Mosstafa Kazemi

摘要

N-aryl amides hold significant importance in organic chemistry due to their widespread presence in pharmaceuticals, agrochemicals, and various bioactive compounds. As a result, catalysts and preparation methodologies for amide derivatives have long been a target of active investigation of interest. In the current work, a simple and accessible route was adopted for preparation of a magnetic catalyst [Fe3O4@SiO2-DHB/DI(S-NH)-Pd (0)] and then its catalysis in three-component amide synthesis via carbonylation reaction between aryl iodides and amines was examined. In experiments, its efficiency in producing a range of amides with high yields in a short and under mild conditions was unequivocally confirmed, and its efficiency in producing a range of amides with high yields in a short and under mild conditions was confirmed unequivocally through experiments. High yields of the desired compound ease in catalyst separation, high reusability of catalysts, mild reaction conditions, ease in accommodation of a range of substrates, and a thorough analysis for determination of the catalyst and produced compounds for characterization and purification have been taken as key features of this work.

Graphical Abstract