The role of cognitive behavioural therapy in migraine with co-existing insomnia: systematic review and meta-analysis
摘要
Migraine and insomnia frequently co-occur, sharing neural pathways and neurotransmitters, complicating treatment. Cognitive behavioural therapy (CBT) is an established intervention for insomnia and chronic pain, but its role in migraine with comorbid insomnia remains unclear.
MethodsFollowing PRISMA guidelines, a systematic review and meta-analysis of PubMed, Cochrane, and Google Scholar databases (inception–12 August 2024) identified studies assessing CBT in patients with migraine and insomnia. Outcomes included treatment engagement, sleep parameters, and headache characteristics.
ResultsFour studies (137 participants, mean age 30 years) met the inclusion criteria. Treatment feasibility ranged from 80 to 90% and acceptability exceeded 80%. Pooled analysis revealed a significant reduction in migraine severity (MD = − 0.55, 95% CI: − 0.97 to − 0.12) but no significant change in migraine disability (MIDAS), sleep efficiency, or total sleep hours. Qualitative synthesis suggested improvements in sleep quality and headache frequency. Findings indicated variability by age group, intervention format, and assessment methods.
ConclusionPreliminary evidence suggest that CBT may be beneficial in reducing migraine severity and frequency in patients with comorbid insomnia, though effects on disability and objective sleep metrics are inconsistent. Heterogeneity in study designs and small sample sizes limits generalisability. Larger, standardised trials are warranted to optimise CBT protocols and explore integration with pharmacological therapies.