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<p>Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by dopaminergic neuron loss and abnormal protein aggregation. While current treatments offer symptomatic relief, they do not alter the course of disease progression. In recent years, the study of cross-species models has gained traction in uncovering novel therapeutic insights. This paper explores the genetic underpinnings of PD, focusing on key mutations in genes such as SNCA, LRRK2, PINK1, PRKN, and DJ-1, and the associated molecular dysfunctions that lead to neuronal degeneration. It further examines the biological advantages of zebrafish (<i>Danio rerio</i>) and naked mole-rats (<i>Heterocephalus glaber</i>), two organisms with unique regenerative or neuroprotective traits, and evaluates their relevance as alternative models for PD research. By comparing these species and their mechanisms of resilience, the paper discusses the translational potential of genetic, stem cell, and AI-integrated approaches in advancing future therapies. The findings highlight the value of interdisciplinary, cross-species research in addressing current limitations and guiding innovative strategies for neurodegenerative disease intervention.</p>

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Comparative molecular signatures of neuroprotection in Parkinson’s disease across zebrafish and naked mole rat models

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月12日

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  • Ayush Likhar,
  • Nilima Warke

摘要

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by dopaminergic neuron loss and abnormal protein aggregation. While current treatments offer symptomatic relief, they do not alter the course of disease progression. In recent years, the study of cross-species models has gained traction in uncovering novel therapeutic insights. This paper explores the genetic underpinnings of PD, focusing on key mutations in genes such as SNCA, LRRK2, PINK1, PRKN, and DJ-1, and the associated molecular dysfunctions that lead to neuronal degeneration. It further examines the biological advantages of zebrafish (Danio rerio) and naked mole-rats (Heterocephalus glaber), two organisms with unique regenerative or neuroprotective traits, and evaluates their relevance as alternative models for PD research. By comparing these species and their mechanisms of resilience, the paper discusses the translational potential of genetic, stem cell, and AI-integrated approaches in advancing future therapies. The findings highlight the value of interdisciplinary, cross-species research in addressing current limitations and guiding innovative strategies for neurodegenerative disease intervention.