Scholarlink

Purpose <p>Evaluate the perispinal neurovascular response (NVR) in a pilot case-control study of 3 incomplete spinal cord transection patients, using non-invasive functional near-infrared spectroscopy (fNIRS).</p> Methods <p>The NVR was evaluated in 3 patients with SCI (one AIS-C and two AIS-B) using fNIRS and compared with a healthy group of 42 subjects. NVR was triggered by painless electrical stimulation of the median nerve. HbO<sub>2</sub> changes were measured with an 8-channel fNIRS at cervical and lumbar levels.</p> Results <p>Patient 1 (T12 injury, 8-month rehabilitation) shows near-normal NVR in the lower thoracic channels, consistent with AIS-C recovery. Patient 2 (T11 injury, 10-month rehabilitation, severe neuropathic pain) with AIS-B status, and Patient 3 (T7 injury, 36-month rehabilitation) exhibited attenuated upper-thoracic NVR responses, correlating with AIS-B status. Median nerve conduction velocities were normal across patients.</p> Conclusion <p>fNIRS detected distinct NVR patterns correlated with injury level and rehabilitation progress, suggesting its utility for tracking functional recovery. This first-in-human application highlights fNIRS as a promising tool for assessing spinal cord injury.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Altered neurovascular responses recorded after incomplete spinal cord injury recorded by a noninvasive near-infrared spectroscopy in a pilot case-control report

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月6日

查看全文
  • Juan P. Appelgren-Gonzalez,
  • Raúl Caulier-Cisterna,
  • Juan E. Oyarzún,
  • Sergio Uribe,
  • Antonio Eblen-Zajjur

摘要

Purpose

Evaluate the perispinal neurovascular response (NVR) in a pilot case-control study of 3 incomplete spinal cord transection patients, using non-invasive functional near-infrared spectroscopy (fNIRS).

Methods

The NVR was evaluated in 3 patients with SCI (one AIS-C and two AIS-B) using fNIRS and compared with a healthy group of 42 subjects. NVR was triggered by painless electrical stimulation of the median nerve. HbO2 changes were measured with an 8-channel fNIRS at cervical and lumbar levels.

Results

Patient 1 (T12 injury, 8-month rehabilitation) shows near-normal NVR in the lower thoracic channels, consistent with AIS-C recovery. Patient 2 (T11 injury, 10-month rehabilitation, severe neuropathic pain) with AIS-B status, and Patient 3 (T7 injury, 36-month rehabilitation) exhibited attenuated upper-thoracic NVR responses, correlating with AIS-B status. Median nerve conduction velocities were normal across patients.

Conclusion

fNIRS detected distinct NVR patterns correlated with injury level and rehabilitation progress, suggesting its utility for tracking functional recovery. This first-in-human application highlights fNIRS as a promising tool for assessing spinal cord injury.