Scholarlink

<p>White matter hyperintensities (WMHs), a major neuroimaging biomarker of cerebral small vessel disease (CSVD), are increasingly recognized as predictors of dementia risk. The subregional distribution and diverse imaging phenotypes of WMHs, including spatial distribution patterns, morphological characteristics, signal intensity, and concomitant lesions, are correlated with distinct mechanisms and aetiologies. This systematic review synthesizes evidence from 31 studies identified through comprehensive searches of PubMed, Embase, Web of Science and the Cochrane Library, following PRISMA guidelines. A key finding is that frontal/deep confluent WMHs with lacunes in the deep white matter are associated with mixed dementia characterized by CSVD and amyloid-β (Aβ) deposition. In contrast, posterior periventricular WMHs coexisting with hippocampal and temporal lobe atrophy and co-localized Aβ deposition serve as early biomarkers of Alzheimer’s disease. Cerebral amyloid angiopathy related WMHs are characterized by juxtacortical multispot patterns and lobar microbleeds, resulting from vascular Aβ deposition and glymphatic system dysfunction. These findings highlight the etiological heterogeneity of WMHs, where spatial distribution patterns and associated imaging features provide critical insights into underlying pathological mechanisms. The identification of these phenotype-specific correlations offers a framework for improving early diagnosis and developing targeted interventions for dementia subtypes.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Phenotypes of white matter hyperintensities, mechanisms and aetiological differentiation: future targets pre-dementia—a systematic review

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年6月18日

查看全文
  • Dean Gu,
  • Sibo Liu,
  • Yuying Zhang,
  • Zilin Zhao,
  • Hang Li,
  • Yanzhao Li,
  • Xiaoyan Lan,
  • Long Wang,
  • Jinjie Liu,
  • Chenhua Ji

摘要

White matter hyperintensities (WMHs), a major neuroimaging biomarker of cerebral small vessel disease (CSVD), are increasingly recognized as predictors of dementia risk. The subregional distribution and diverse imaging phenotypes of WMHs, including spatial distribution patterns, morphological characteristics, signal intensity, and concomitant lesions, are correlated with distinct mechanisms and aetiologies. This systematic review synthesizes evidence from 31 studies identified through comprehensive searches of PubMed, Embase, Web of Science and the Cochrane Library, following PRISMA guidelines. A key finding is that frontal/deep confluent WMHs with lacunes in the deep white matter are associated with mixed dementia characterized by CSVD and amyloid-β (Aβ) deposition. In contrast, posterior periventricular WMHs coexisting with hippocampal and temporal lobe atrophy and co-localized Aβ deposition serve as early biomarkers of Alzheimer’s disease. Cerebral amyloid angiopathy related WMHs are characterized by juxtacortical multispot patterns and lobar microbleeds, resulting from vascular Aβ deposition and glymphatic system dysfunction. These findings highlight the etiological heterogeneity of WMHs, where spatial distribution patterns and associated imaging features provide critical insights into underlying pathological mechanisms. The identification of these phenotype-specific correlations offers a framework for improving early diagnosis and developing targeted interventions for dementia subtypes.