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Background <p>Hydrocephalus, as a common complication following aneurysmal subarachnoid hemorrhage (aSAH), not only leads to neurological dysfunction in patients but is also associated with a relatively high mortality rate.</p> Methods <p>This study is a prospective, single-center, randomized controlled trial. It is planned to recruit 256 patients with aSAH (parallel design, with a 1:1 allocation). Subjects will be assigned to the continuous lumbar drainage (LD) group and the intermittent LD group after undergoing surgical treatment (within 72&#xa0;h). The primary outcome events will be defined as the degree of improvement in patients’ 180 (± 7 days) modified Rankin Scale (mRS) and Glasgow Outcome Scale (GOS) scores, incidence of shunt-dependent hydrocephalus, and 30&#xa0;days mortality after randomization. Recruitment will be finished by November 2027. All the patients will be followed for at least 180 (± 7 days). The trial is scheduled to complete in 2028.</p> Discussion <p>This study aims to explore the safety and effectiveness of different LD methods after aSAH, evaluate whether there are different impacts on the neurological prognosis of patients, and determine whether the incidence of shunt-dependent hydrocephalus varies among different methods. It is intended to provide high-quality evidence-based medical evidence for the clinical management of hydrocephalus after aSAH.</p> Trial registration <p>ChiCTR2500096647 with chictr.org.cn. Registered on 27 January 2025.</p>

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Continuous versus intermittent lumbar CSF drainage in aneurysmal arachnoid hemorrhage: a prospective, randomized controlled trial protocol

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月9日

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  • Kuangyang Yu,
  • Wen Tan,
  • Lu Jiang,
  • Jinwei Pang,
  • Fengwang Xue,
  • Kunyang Bao,
  • Changren Huang,
  • Yong Jiang,
  • Jianhua Peng

摘要

Background

Hydrocephalus, as a common complication following aneurysmal subarachnoid hemorrhage (aSAH), not only leads to neurological dysfunction in patients but is also associated with a relatively high mortality rate.

Methods

This study is a prospective, single-center, randomized controlled trial. It is planned to recruit 256 patients with aSAH (parallel design, with a 1:1 allocation). Subjects will be assigned to the continuous lumbar drainage (LD) group and the intermittent LD group after undergoing surgical treatment (within 72 h). The primary outcome events will be defined as the degree of improvement in patients’ 180 (± 7 days) modified Rankin Scale (mRS) and Glasgow Outcome Scale (GOS) scores, incidence of shunt-dependent hydrocephalus, and 30 days mortality after randomization. Recruitment will be finished by November 2027. All the patients will be followed for at least 180 (± 7 days). The trial is scheduled to complete in 2028.

Discussion

This study aims to explore the safety and effectiveness of different LD methods after aSAH, evaluate whether there are different impacts on the neurological prognosis of patients, and determine whether the incidence of shunt-dependent hydrocephalus varies among different methods. It is intended to provide high-quality evidence-based medical evidence for the clinical management of hydrocephalus after aSAH.

Trial registration

ChiCTR2500096647 with chictr.org.cn. Registered on 27 January 2025.